Gene Therapy Immunology
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More About This Title Gene Therapy Immunology


  • Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic
  • Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases
  • Broad appeal - applicable for  immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research


Roland W. Herzog, Ph.D., is Associate Professor of Pediatrics at the University of Florida in Alachua, Florida. Dr. Herzog is a regular presenter at the annual American Society for Gene Therapy meeting, and his popular course on the topic of immunology and gene therapy is the basis for this exciting new book.


1. The immunology of gene transfer: an overview (David Lillicrap).

2. Innate immune responses to nucleic acids (Ishii and Akira).

3. The anti-viral Innate immune response (Daniel Muruve).

U. Calgary, Canada.

4. Immune responses to adenoviral vectors (Dmitry M. Shayakhmetov).

5. Immune responses to lentiviral vectors (Lung-Ji Chang).

6. Immune responses to adeno-associated virus vectors (Hildegund Ertl).

7. Immunology after in utero and neonatal gene transfer (Simon Waddington).

8. Immunology of hepatic gene transfer (Roland Herzog).

9. Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases (Pedro Lowenstein).

10. Immunology of cutaneous gene transfer (Soosan Ghazizadeh).

11. Immune responses to pulmonary gene therapy (Terence Flotte).

12. Induction of immune tolerance through gene transfer to hematopoietic stem cells (John Iacomini).

13. Reconstitution of the immune system by gene therapy (Adrian Thasher).

14. Genetics of the Immune Response to Proteins Expressed After Gene Transfer (Jay Lozier).

15. Immune modulation and transient suppression strategies (Valder Arruda).

16. Gene therapy for autoimmune diseases (Nicholas Giannoukakis).

17. Engineering of viral capsids to evade the host immune system (.

Hildegard Büning).


"This book provides a thorough and comprehensive description of the problems faced by gene therapists, and their continuing need to overcome the immune system to allow effective gene therapy in future clinical trials. It is well placed to be a useful and informative textbook, which I would highly recommend." (Immunology News, May 2009)

“This book, put together by experts, delivers a fresh approach to thinking about gene therapy and delivery of the vectors. The information is as current as a multiauthored book can be and would be useful to students as well as physicians.” (Doody's Reviews, March 2009)