Title Details

Harold C. Smith, PhD, is Professor in the Department of Biochemistry and Biophysics at the University of Rochester and the founder and Chief Scientific Officerof OyaGen, a biotech company that develops drugs that target editing enzymes. Dr. Smith organized the first Gordon Research Conference on RNA Editing in 1997 and holds four patents.

Acknowledgements.

Contributors.

Part I: Diversification of the Proteome through RNA and DNA Editing.

Chapter 1. Diversifying Exon Code Through A-To-I RNA Editing.

Chapter 2. Antibody Gene Diversification by Aid-Catalyzed DNA Editing.

Chapter 3. Protein-Protein and RNA-Protein Interactions in U-Insertion/Deletion RNA Editing Complexes.

Chapter 4. Machinery of RNA editing in Plant Organelles.

Part II: Functional Coordination of RNA Editing With Other Cellular Mechanisms.

Chapter 5. Transfer RNA Editing Enzymes: At the Crossroads of Affinity and Specificity.

Chapter 6. A-To-I Editing as a Co-Transcriptional RNA Processing Event.

Chapter 7. Studying and Working with Ribonucleoproteins that Catalyze H/ACA Guided RNA Modification.

Chapter 8. Functional Roles of Spliceosomal _SNRNA Modifications in Pre-_mRNA Splicing.

Chapter 9. A Role for A-To-I Editing in Gene Silencing.

Chapter 10. biological Implications and Broader-Range Functions For Apobec-1 and Apobec-1 Complementation Factors (ACF)

Chapter 11. Antiviral Function of APOEC3 Cytidine Deaminases.

Part III: Predictive Structures.

Chapter 12. A-To-I Editing of _ALU Repeats.

Chapter 13. RNA Editing in Dinoflagellates and Implications for the Evolutionary History of the Editing Machinery.

Part IV: Structural Approaches.

Chapter 14. The Box C/D RNPs: Evolutionarily Ancient Nucleotide Modification Complexes.

Chapter 15. Structural Features of the Adar Family of Enzymes and Their Substrates.

Chapter 16. Chemistry, Phylogeny, and three-Dimensional Structure of the Apobec Protein Family.

Index.