Treatment-Resistant Depression
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More About This Title Treatment-Resistant Depression


The first book devoted to a challenging disorder that affects millions of people around the world.  Essential reading for all psychiatrists who manage these patients.


Professor Dr Kasper is Professor of Psychiatry and Chairman of the Department of General Psychiatry at the Medical University of Vienna, Austria. He is Honorary Professor at the University of Hong Kong, China.  He concentrates on the biological bases of mental disorders and their possible treatment approaches. He has conducted studies in psychopathological as well as clinical areas. Dr Kasper is a frequent national and international speaker and is actively involved in research programmes studying depression, anxiety, psychosis, and dementia, authoring over 800 research reports and reviews. Dr Kasper serves on the editorial boards of numerous learned journals, including European Archives of Psychiatry and Neuroscience, European Psychiatry, and European Neuropsychopharmacology. He is Co-editor in-chief of the International Journal of Psychiatry in Clinical Practice.

Professor Montgomery was Professor of Psychiatry at Imperial College, University of London until his retirement in 1996 when he became Emeritus Professor of Psychiatry. He has great breadth of experience in the field of psychotropic medicine with seminal work in depression, anxiety disorders, suicide prevention and schizophrenia. He has published 26 books and more than 400 papers. Professor Montgomery is editor of International Clinical Psychopharmacology and was editor of European Neuropsychopharmacology for 20 years. He also serves on the editorial board of numerous scientific journals.


List of Contributors vii

Foreword ix

1 Definitions and Predictors of Treatment-resistant Depression 1
Daniel Souery and William Pitchot

2 Treatment-resistant Depression: A Separate Disorder – A New Approach 21
Hans-Jürgen Möller, Florian Seemüller, Rebecca Schennach and Ramesh K. Gupta

3 Genetics of Treatment-resistant Depression 43
Chiara Fabbri, Stefano Porcelli and Alessandro Serretti

4 Is There a Role for Switching Antidepressants in Treatment-resistant Depression? 91
Stuart Montgomery

5 The Role of Atypical Antipsychotics in Inadequateresponse and Treatment-resistant Depression 107
Siegfried Kasper and Elena Akimova

6 Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression 129
Robert Haußmann and Michael Bauer

7 The Role of Nonpharmacological Interventions in Treatment-resistant Depression 159
Thomas E. Schläpfer and Sarah Kayser

8 The Role of Psychotherapy in the Management of Treatment-resistant Depression 183
Michael E. Thase

Index 209


“After all, this book is recommended for the young psychiatrist, who wants to read an easy introduction to the fascinating world of treatment of resistant depression.”  (Acta Psychiatrica Scandinavica, 9 November 2013)

“This is a monograph, which could be of great interest to psychiatrists managing patients with TRD. The chapters are written clearly, and the references are comprehensive and up-to-date.”  (Human Psychopharmacology: Clinical & Experimental, 6 November 2013)

“The editors should be congratulated for accomplishing the amazing feat of presenting so much information in such a compact book. With an investment of just a few hours, readers can be updated on a very complicated subject . . . The editors should be commended on detailing a variety of treatment options, including nonpharmacological options, which other books fail to emphasize.”  (Doody’s, 23 August 2013)