Liver Transplantation - Clinical Assessment andManagement
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More About This Title Liver Transplantation - Clinical Assessment andManagement


Liver Transplantation: Clinical Assessment and Management is the perfect tool for all gastroenterologists, hepatologists and transplant surgeons managing patients with liver disease awaiting and undergoing transplantation. 

Led by James Neuberger, world experts in hepatology and transplantation provide a chronological, step-by-step approach to best clinical management and patient care. 

Evidence-based throughout and with reference to the very latest practice guidelines from major societies such as EASL and AASLD, the book covers:

  • When to refer a patient for liver transplantation
  • Selection, assessment and management on the list
  • Transplantation for acute liver failure
  • Donation and  allocation
  • Care of the liver transplant recipient

80 high definition videos of transplant surgery allow you to watch the experts in action and provide an outstanding visual and teaching element.  In addition, key points, potential pitfalls, management algorithms, and useful weblinks all help ensure rapid reference browsing. 

If you're managing patients requiring a liver transplant, this multimedia resource will save you time and effort by putting essential information within easy reach.


James Neuberger MD, Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. Professor Neuberger is the Associate Medical Director at NHS Blood and Transplant, and Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. He has worked in many aspects of liver disease and transplantation and been involved with UK Transplant (UKT) for over 10 years. He is also Editor-in-Chief of LWW's Transplantation, the journal of the Transplantation Society, and on the board of several liver and transplant journals. He?has 295 articles listed on PubMed.

Dr James Ferguson MD, Consultant Hepatologist, Queen Elizabeth Hospital, Birmingham. Interests include: cardiovascular and renal dysfunction after liver transplantation and the complications of portal hypertension; portal hypertension, vascular disorders of the liver, alcoholic liver disease and adolescent transition.

Dr Philip Newsome, Senior Lecturer in Hepatology and Clinical Director of the Birmingham University Stem Cell Centre, Birmingham, UK. Dr Newsome has had many major research papers in scientific journals published as well as reviews and book chapters in the fields of virology, cancer and tumour immunology.?He has received major grants from NIHR, Wellcome Trust, UKSCF, BBSRC and the Medical Research Council.?He is an enthusiastic communicator on the theme of translational stem cell work and non-alcoholic fatty liver disease and gives frequent talks to various groups at both the local and national level.


List of Contributors, ix

Foreword, xii

Preface, xiv

Acknowledgements, xv

About the Companion Website, xvi

Abbreviations, xvii

PART 1 When to Refer a Patient for Liver Transplantation

1 General Considerations, 3
S. Tamir Rashid and Alexander E. Gimson

2 Prognostic Models in Liver Transplantation, 18
James Neuberger

PART 2 Selection, Assessment and Management on the List

3 Assessing the Potential Transplant Recipient, 29
Diarmaid D. Houlihan and Philip N. Newsome

4 Consent, 39
Christopher J.E. Watson

5 Management on the Waiting List, 47
Sumeet K. Asrani and Jayant A. Talwalkar

6 Specific Diseases, 60
Ian A. Rowe and David J. Mutimer

7 Specific Issues of Selection including Non-Compliance, Futility, Nutritional and Social Issues, 73
Ken Simpson

PART 3 Transplantation for Acute Liver Failure

8 Assessment of the Patient with Acute Liver Failure, 85
Ashley Barnabas and John O’Grady

9 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation, 93
James Neuberger

PART 4 Donation and Allocation

10 Liver Donation, 103
Gabriel C. Oniscu

11 Liver Allocation, 116
Richard B. Freeman, Jr

12 Alternatives to Orthotopic Liver Replacement, 125
James Neuberger

13 Surgical Aspects of Liver Transplantation, 129
Thamara Perera and Simon Bramhall

PART 5 Care of the Liver Transplant Recipient

14 Introduction to Outcomes and Follow-Up, 147
James Neuberger

15 The Immune System in Liver Transplantation: Rejection vs.Tolerance, 160
Palak J. Trivedi and Nick D. Jones

16 Immunosuppression in Liver Transplantation, 184
Aaron James Chan and John R. Lake

17 Microbiological Prophylaxis in Liver Transplantation, 197
Matthew J. Armstrong and Philip N. Newsome

18 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests, 208
Joanna A. Leithead and James Ferguson

19 Managing Rejection, 227
Palak J. Trivedi and James Neuberger

20 Management of Renal Function, 248
James Ferguson

21 Management of Post-Transplant Ascites, 256
Chris Corbett and Philip N. Newsome

22 Cytomegalovirus and the Liver Transplant Recipient, 261
James Ferguson

23 Immunisation and Liver Transplantation, 268
James Neuberger

24 Contraception and Pregnancy, 274
Carlo B. Ramirez, Cataldo Doria, Michael J. Moritz, John M. Davison and
Vincent T. Armenti

25 Common Drug Interactions, 283
Amanda Smith

26 Management of Recurrent Disease, 290
Michael R. Lucey

27 Managing Cardiovascular Risk in the Liver Transplant Recipient, 299
Joanna K. Dowman and Philip N. Newsome

28 Bone Disease in Liver Transplantation, 309
John Ayuk

29 Malignancy after Liver Transplantation, 316
James Neuberger

30 Post-Transplant Lymphoproliferative Disorder, 325
Joseph F. Buell, Nathan J. Shores, Thomas G. Gross, Jeremy R. Chapman and Angela C. Webster

Colour plate section facing p. 170

Index, 337