Epilepsy in Women
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More About This Title Epilepsy in Women

English

Epilepsy requires careful management and monitoring through a woman’s life

Epilepsy is a complex disease. The hormonal changes women experience, both day-to-day menstrual fluctuations and the longer waxes and wanings of a reproductive lifetime, make the management of epilepsy even more complicated. At some point, the well-being of a second person, a fetus, might also have to be taken into account.

Epilepsy in Women
provides a detailed guide to this challenge. The wide-ranging approach encompasses all aspects of a woman’s life including:

  • Social and psychological impacts
  • The impact in reproductive life
  • Contraception
  • Pregnancy
  • Fetal health and long term developmental outcomes
  • Lactation
  • Menopause

Each practical chapter begins and ends with a case study that demonstrates the more general challenge. The authors develop themes to provide clinical guidance based on evidence and experience.

Written and edited by an international cast of experts, Epilepsy in Women provides crucial tips and recommendations for neurologists and gynecologists who need to be aware of the subtle effects of epilepsy on woman’s life.

English

Cynthia L. Harden, MD, Chief of the Comprehensive Epilepsy Care Institute, North Shore LIJ Health System and Professor of Neurology, Hofstra North Shore-LIJ School of Medicine, USA.

Sanjeev V Thomas, MD, Professor of Neurology, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695 011, India and Fulbright Visiting Professor, Ohio State University, Columbus, USA.

Torbjörn Tomson, MD, Professor of Neurology, especially epileptology, Department of Clinical Neuroscience, Karolinska Institutet, and consultant/senior physician at Department of Neurology, Karolinska University Hospital, Sweden.

English

Preface, vii

Contributors, ix

1 Gender Difference in Epidemiology and Comorbidities of Epilepsy, 1
Ettore Beghi and Massimiliano Beghi

2 The Social and Psychological Impacts of Epilepsy, 11
Sanjeev V. Thomas and Aparna Nair

3 Neurosteroid influences on neuronal excitability: The menstrual cycle and catamenial epilepsy as dynamic models, 23
Doodipala Samba Reddy

4 Catamenial Epilepsy, 41
Erik Taubøll, Line S. Røste and Sigrid Svalheim

5 Impact of Epilepsy and AEDs on Reproductive Health, 53
Gerhard Luef

6 Contraception and Epilepsy, 64
Anne R. Davis and Kathleen M. Morrell

7 Diagnostic Challenges with Seizures in Pregnancy, 75
Sanjeev V. Thomas

8 Seizure Control During Pregnancy, 91
Anne Sabers

9 Effect of Pregnancy on AED Kinetics, 101
Peter B. Forgacs and Page B. Pennell

10 Fetal and Maternal Risks with Seizures, 115
Vilho K. Hiilesmaa and Kari A. Teramo

11 Obstetrical Outcome and Complications of Pregnancy, 128
Ingrid Borthen and Nils Erik Gilhus

12 Mechanisms of Teratogenic Effects of AEDs, 136
Lynsey E. Bruce, Ana M. Palacios, Bogdan J. Wlodarczyk and Richard H. Finnell

13 Major Congenital Malformations in Offspring of Women with Epilepsy, 148
Dina Battino and Torbjörn Tomson

14 Fetal AED Syndromes, 164
Usha Kini

15 Postnatal Cognitive Development, 170
Evan R. Gedzelman and Kimford J. Meador

16 M anagement of the Postpartum Period and Lactation, 184
Autumn M. Klein

17 M anagement of Epilepsy and Pregnancy, 196
Sanjeev V. Thomas, Torbjörn Tomson and Cynthia L. Harden

18 Perimenopause and Menopause, 200
Cynthia L. Harden

19 Bone Health, 205
Alison M. Pack

Index, 211

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