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More About This Title Handbook of Human Molecular Evolution 2VSet
English
—Richard Dawkins
"This is a marvellous book… It should be in every university library - preferably in several copies - and every reader of this journal should add it to their next grant application. It really is that good... I have already found this book to be invaluable… For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics… Any scientist working on humans or other animals will find many things in these pages that will stimulate, inform and inspire. The authors, editors and publishers are to be congratulated for their work… order a copy now!"
—HUMAN GENETICS
"The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin. The book is well-timed, with biologists, theologians and sociologists engaged in intense debate on the Darwinian Theory on the origin of species, evolution and natural selection… There is little doubt that this marvellous publication should be in the library of universities and academic institutions dealing with basic and applied biology research and education… It will not be surprising if the individual academic or researcher decides to invest in this resource and enrich their personal collection of leading books in genetics and genomics."
—GENOMIC MEDICINE
A Unique Collection of High-Quality Articles – Derived from the Acclaimed Encyclopedia of Life Sciences
The revolution in human molecular genetics which has taken place over the last three decades has yielded a wealth of information not only on the structure and function of our genes, but also on gene expression, mutation and polymorphic variation. Over the last five years, the focus has moved from genes to genomes. Even though the annotation of our ~30,000 genes is still in progress, genome-wide studies have already yielded abundant evidence for the signatures of past selection and adaptive evolution within human gene sequences. Further, the completion of the sequencing of the 3 billion base-pair human genome, coupled with the increasing availability of other vertebrate genome sequences, has ushered in a new era of comparative genomics. We are now able to identify many of the molecular events (from the chromosomal level down to the single base-pair) that have occurred during vertebrate, mammalian, primate and hominid evolution. Indeed, the detailed comparison of the human and chimpanzee genomes has begun to reveal some of the genetic changes that have been involved in the development of human lineage-specific traits. We are thus acquiring the ability to ask searching questions about our origins, about the demographic processes associated with the global radiation of humankind, as well as some of the unique adaptations that make us human.
Evolutionary biology has become so broad that its impact may be felt across the spectrum of the biological sciences. The aim of the Handbook of Human Molecular Evolution is relatively straightforward: to bring together under the same cover the many and varied strands of our knowledge of human/primate/vertebrate molecular evolution. Hence, the 282 chapters that comprise this essential reference work have been thematically arranged into twelve sections, covering the whole scope of research into human molecular evolution:
General Concepts in Evolutionary Genetics
Mutation, Adaptation and Natural Selection
Evolutionary and Population Genetics
Human Evolution
Human Genome Evolution
Evolution of Human Gene Structure and Function
Evolution of Gene Expression
Mitochondrial Genome Evolution
Chromosomal Evolution
Comparative Genomics
Evolution and Disease Susceptibility
Analysis of Ancient DNA
This conceptual outline informed the selection of the chapters themselves and the connections between them. Some of these chapters are intended to be introductory, aimed at undergraduates and non-specialists. They provide basic information and a list of recommended further reading to encourage the reader to explore a topic in more depth. This approach helps the student reader progress from textbook material to primary literature. Some chapters are overviews that address topics of broad interest and importance, while others focus on quite specialized topics. These chapters are written for postgraduate students and research workers; they contain more detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source. The chapters are richly supplied with website information to allow access to relevant data sources over the internet. The self-contained, peer-reviewed articles in this unique handbook have been written by leading scientists in each field.
Key topics include the evolution of enzyme function, the use of nucleic acid divergence as a "molecular clock", the origin of non-functional or junk DNA, the role of gene duplication in the emergence of novel gene function and the identification of molecular changes responsible for various human characteristics especially those pertaining to infection, cognition, disease and disease susceptibility.
The Handbook of Human Molecular Evolution has adopted an integrated approach to the study of human evolution and seeks throughout to emphasize the interplay between molecular genetic concepts and principles on the one hand, and information acquisition and interpretation on the other. In this way, it is hoped that the ‘documents of evolutionary history’ written into the fabric of our genome, will become accessible to the widest possible audience.
English
David N. Cooper has been Professor of Human Molecular Genetics at Cardiff University since 1996. His research interests focus largely on molecular mechanisms of mutagenesis and genotype-phenotype relationships in a variety of different inherited disorders, population genetics, gene expression, cancer genetics, growth hormone genetics, and molecular evolution. He has written or co-authored Human Gene Mutation (1993), The Molecular Genetics of Haemostasis and Its Inherited Disorders (1994), Venous Thrombosis: From Genes to Clinical Medicine (1997), Human Gene Evolution (1999) and The Molecular Genetics of Lung Cancer (2005). He has also co-edited The Functional Analysis of the Human Genome (1995), Gene Therapy (1996), Neurofibromatosis Type 1: From Genotype to Phenotype (1998) and Fascioscapulohumeral Muscular Dystrophy: Clinical Medicine and Molecular Cell Biology (2004). He acted as Editor-in-Chief of the Nature Encyclopedia of the Human Genome (2003) and is currently Editor of the Genetics & Disease section of the Wiley Encyclopedia of Life Sciences. He has been European Editor of the journal Human Genetics since 1997 and Curator of the Human Gene Mutation Database (www.hgmd.org) since 1996.
Hildegard Kehrer Sawatzki is a Senior Research Fellow in the Institute of Human Genetics, University of Ulm, Germany where she has been a group leader since 2000. She has published extensively in the field of molecular medicine and molecular evolution. Alongside her long-term work on the tumour predisposition syndrome, type 1 neurofibromatosis, she has developed a keen interest in the comparative analysis of the human, chimpanzee and macaque genomes in order to identify inter-species genetic differences, particularly those which are human-specific. She has characterized, at the molecular level, the microscopically-visible chromosomal differences between human and chimpanzee known as pericentric inversions. In addition, she has performed detailed genomic comparisons which have contributed to the identification of the hundreds of small submicroscopic inversions, insertions, deletions and copy number differences that are largely responsible for the genetic divergence of the primates. In 2007, she received the Merckle Research Prize for her work on evolutionary and disease-associated chromosomal breakpoints.
David Cooper and Hildegard Kehrer-Sawatzki are the ELS section editors for Genetics & Disease and Evolution & Diversity of Life, respectively.
English
James F Crow Evolution: Selectionist View
Andreas Wagner Evolution: Neutralist View
Andreas Wagner The Neo-selectionist Theory of Genome Evolution
Giorgio Bernardi Fitness and Selection
Brian Charlesworth Genetic Drift in Human Populations
Andrew J Bohonak Heterozygosity
Wen-Hsiung Li Effective Population Size
Michael C Whitlock Population Differentiation: Measures
Stefano Mona
Giorgio Bertorelle Evolutionary Distance
Wen-Hsiung Li Gene Trees and Species Trees
Wen-Hsiung Li Homologous, Orthologous and Paralogous Genes
Wen-Hsiung Li Evolution: Convergent and Parallel Evolution
Caro-Beth StewartMutation, Adaptation and Natural Selection Genetic Variation: Polymorphisms and Mutations
Alan F Wright Polymorphisms: Origins and Maintenance
Kenneth M Weiss Molecular Evolution: Introduction
David Penny Molecular Evolution: Overview
Jan Klein Molecular Evolution: Genetics of Adaptation
Michael Travisano Neutral Theory of Molecular Evolution
Naoyuki Takahata Molecular Evolution: Nearly Neutral Theory
Tomoko Ohta Molecular Evolution: Rates
Lindell Bromham Molecular Evolution: Patterns and Rates
Lindell Bromham Nucleotide Substitution: Rate of
Wen-Hsiung Li Synonymous and Nonsynonymous Rates
Soojin Yi Mutational Change in Evolution
Dan Graur Mutations and New Variation: Overview
Mark O Johnston Single-base Mutation
Dan Graur Mutation Rate
Bertram Müller-Myhsok Mutation Rates: Evolution
David Metzgar Spectrum of Mutations in the Human Genome Inferred by Single Nucleotide Polymorphisms
Zhao Zhongming Mutational Biases
Lev Y Yampolsky
Arlin Stoltzfus Mutations: Dating
Roberto Colombo Diffusion Theory
Gil McVean Molecular Clocks in Mammals
Wen-Hsiung Li
Kateryna D Makova Molecular Clocks
Andrew Peter Martin Purifying Selection: Action on Silent Sites
R Nielsen
H Akashi Selection against Amino Acid Replacements in Human Proteins
Sankar Subramanian Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection
Ryosuke Kimura
Jun Ohashi Positive Selection on Genes in Humans as Compared to Chimpanzees
Margaret A Bakewell
Jianzhi Zhang Selection Operating on Protein-coding Genes in the Human Genome
Diogo Meyer
Eugene E Harris Selective and Structural Constraints
Austin L Hughes Substitution Matrices
Stephen F Altschul Fixation Probabilities and Times
Sarah P Otto
Michael C Whitlock Genetic Code: Evolution
Edward N Trifonov Codon Usage in Molecular Evolution
Richard L Grantham Linkage Disequilibrium
Peter JP Croucher Recombination and Human Genetic Diversity
Chris CA Spencer Comparison of Rates and Patterns of Meiotic Recombination between Human and Chimpanzees
Jan Freudenberg Rapid Evolution of Genes on the Human X-chromosome
Erika M Kvikstad
Kateryna D MakovaEvolutionary and Population Genetics Gene Flow, Haplotype Patterns and Modern Human Origins
Alan R Templeton HapMap Project
Bryan J Traynor
Andrew Singleton Migration
Guido Barbujani Nonrandom Mating
Dennis H O'Neil Human Population Stratification and its Assessment by Microarray Genotyping
Marc Bauchet Sequence Alignment
Julie D Thompson
Olivier Poch Sequence Similarity
Jaap Heringa Phylogenetics
Wen-Hsiung Li Phylogenetic Footprinting
Wyeth W Wasserman
Wynand Alkema Molecular Phylogeny Reconstruction
Sudhir Kumar
Alan Filipski Evolutionary Distance: Estimation
Masatoshi Nei
Jianzhi Zhang Coalescent Theory
Simon Tavaré Stationary Allele Frequency Distributions
Bruce Rannala Developmental Evolution
Susan Lindsay Morphological Diversity: Evolution
Graham Budd Male-driven Evolution
Hans Ellegren Coevolution: Molecular
Ronald M Adkins Concerted Evolution
Daiqing Liao Sociobiology, Evolutionary Psychology and Genetics
Patrick Bateson Are Humans Still Evolving?
Floyd A ReedHuman Evolution Hominids: Molecular Phylogenetics
Ulfur Arnason
Morgan Kullberg Human Evolution: Overview
Bernard A Wood Molecular Clocks: Determining the Age of the Human–Chimpanzee Divergence
Michael I Jensen-Seaman
Kathryn A Hooper-Boyd On the Number of Ancestral Human Species
Darren Curnoe Human Evolution: Early Radiations
Bernard A Wood Human Evolution: Radiations in the Last 300000 Years
Osbjorn M Pearson Modern Humans: Origin and Evolution
Todd R Disotell Modern Human Origins: The `Out of
John H Relethford Origin of Modern Humans: Interpreting the Molecular Evidence
Henry C Harpending Human Populations: Evolution
Rebecca L Cann Human Populations: Origins and Evolution
Rosalind M Harding
John H Relethford Humans: Demographic History
Henry Harpending DNA Markers and Human Evolution
Rebecca L Cann Reconstructing Human History Using Autosomal, Y-Chromosomal and Mitochondrial Markers
Bryndis Yngvadottir
Denise R Carvalho-Silva Population History and Linkage Disequilibrium
Sebastian Zöllner Human Population Genetics: Drift and Migration
Ranajit Chakraborty Human Genetics and Languages
David Comas
Elena Bosch
Francesc Calafell Surnames and Genetics
Mark A Jobling Population History of
Guido Barbujani Genetic Diversity in
Alicia Sanchez-Mazas
Estella S. Poloni Genetic Diversity in the German Population
Michael Krawczak
Timothy T Lu
Sascha Willuweit
Lutz Roewer Genetics and the History of the Basque People
Martin Richards
Cristian Capelli
James F Wilson Genetics and the Origins of the Chinese
Qing-Peng Kong
Hui Pan
Ya-
Reijo Norio Genetics and the Origins of the Irish
Brian McEvoy
Daniel G Bradley Genetics and the Origins of the Polynesians
Geoffrey K Chambers Origins of the Australian and New Guinean Aborigines
Sheila M van Holst Pellekaan Origins of the Austro-Asiatic Populations
B Mohan Reddy
Vikrant Kumar Peopling of
Partha P Majumder Population Genetics of the Ashkenazim
Marina Faerman Roma (Gypsies): Genetic Studies
Bharti Morar
Luba Kalaydjieva The Peopling of the
Theodore G Schurr Primates and the Origin of Culture
WC McGrewHuman Genome Evolution Evolution of Genome Organization
Wolfgang Stephan Genome Organization of Vertebrates
Giorgio Bernardi Evolutionary History of the Human Genome
Giorgio Bernardi Sequencing the Human Genome: Novel Insights into its Structure and Function
Hildegard Kehrer-Sawatzki
David N Cooper Single Nucleotide Polymorphism (SNP)
Anthony J Brookes Human Genetic Diversity
Lynn B Jorde Human and Chimpanzee Nucleotide Diversity
Henrik Kaessmann Divergence between the Human and Chimpanzee Genomes and its Impact on Protein and Transcriptome Evolution
Hildegard Kehrer-Sawatzki
David N Cooper Indels in the Evolution of the Human and Chimpanzee Genomes
Anna Wetterbom
Lucia Cavelier
Tomas F Bergström Inferring the Process of Human–Chimpanzee Speciation
K Ryo Takahasi
Hideki Innan Human Genome Diversity Project (HGDP)
Morris W Foster Blocks of Limited Haplotype Diversity
Yoko Satta Biased Gene Conversion and its Impact on Human Genome Evolution
Nicolas Galtier
Laurent Duret Repetitive DNA: Evolution
Wolfgang Stephan
J Bruce Walsh Simple Sequence Repeats in the Human Genome: Evolution
Donald E Riley
John N Krieger Evolution of Microsatellite DNA
Iris M Vargas Jentzsch
Andrew Bagshaw
Emmanuel Buschiazzo
Angelika Merkel
Neil J Gemmell Evolution of Alpha Satellite DNA
Ðurðica Ugarkovic´ Comparative Genetics of Trinucleotide Repeats in the Human and Ape Genomes
Loris MularoniMacarena Toll-RieraM Mar Albà Endogenous Retroviral Sequences; their Evolutionary Contribution to the Human Genome Jens Mayer Human Endogenous Retroviruses; Evolutionary Dynamics, Chromosomal Location and Host Benefit
Paul Nelson
Graham Freimanis
Denise Roden Evolutionary History and Impact of Human DNA Transposons
Cédric Feschotte Evolution of Human Retrosequences: Alu
Astrid M Roy-Engel
Mark A Batzer
Prescott L Deininger Long Interspersed Nuclear Elements (LINEs): Evolution
Anthony V Furano
Stéphane Boissinot Bacterial DNA in the Human Genome
Jan O Andersson Chromosome-specific Repeats (Low-copy Repeats)
M-C Potier
G Golfier
EE Eichler Telomere
Christa Lese Martin
David H Ledbetter Telomeric and Subtelomeric Repeat Sequences
Dmitri Churikov
Carolyn M Price Subtelomeres: Evolution in the Human Genome
M Katharine Rudd The Evolution of Centromeric DNA Sequences
Joshua J Bayes
Harmit S Malik Segmental Duplications and Their Role in the Evolution of the Human Genome
Yali Xue
Chris Tyler-Smith Copy Number Variation in the Human Genome
Hildegard Kehrer-Sawatzki Gene Duplication: Evolution
Wen-Hsiung Li Gene Families: Formation and Evolution
Tomoko Ohta Gene Families: Multigene Families and Superfamilies
Tomoko Ohta Gene Clustering in Eukaryotes
Jeffrey G Lawrence
Thomas Blumenthal Clustering of Highly Expressed Genes in the Human Genome
Hinco J Gierman
Rogier Versteeg Gene Distribution in Human Chromosomes
Giorgio Bernardi
Salvatore Saccone Evolution of
James Taylor The Impact of Gene Duplication on Human Genome Evolution
James A Cotton Genetic Redundancy
David C Krakauer DNA Methylation: Evolution
Aharon Razin
Ruth Shemer Evolution of Imprinting: Imprinted Gene Function in Human Disease
Benjamin JA Dickins
Gavin Kelsey Imprinting: Evolution
Hamish G Spencer Epigenetic Variation in Humans
Jon F Wilkins Dosage Compensation Mechanisms: Evolution
Ignacio Marín Evolution of X-chromosome Inactivation
Alexander I Shevchenko
Suren M Zakian Ultraconserved DNA Sequence Elements in the Human Genome
Alison P Lee
B Venkatesh The Biological Significance of Conserved Non-Generic DNA
Emmanouil T Dermitzakis Evolutionarily Conserved Noncoding DNA
Anil G Jegga
Bruce J Aronow Human-specific Accelerated Evolution of Noncoding Sequences
Matthew T Webster Rapidly Evolving Regions of the Human Genome
Subhash Mohan Agarwal GC-Rich Isochores in the Interphase Nucleus
Salvatore Saccone
Giorgio BernardiEvolution of Human Gene Structure and Function Gene Structure: Evolution
Tomoko Ohta Gene Evolution and Human Adaptation
Eugene E Harris The Evolution of Introns in Human Genes
Elodie Gazave
Olga Fernando
Arcadi Navarro Intron Evolution in Duplicated Human Genes
Kamel Jabbari
Edda Rayko Intron Loss and Gain
Tobias Mourier
Daniel C Jeffares Introns: Movements
Manyuan Long
Rüdiger Cerff Introns: Phase Compatibility
László Patthy Evolutionarily Conserved Intronic Splicing Regulatory Elements in the Human Genome
Eric L Van Nostrand
Gene W Yeo Evolutionary Conservation of Splice Sites
Michelle L. Hastings
László Patthy Alternative Splicing in the Human Genome and its Evolutionary Consequences
Liliana Florea Dual-coding Regions in Alternatively Spliced Human Genes
Han Liang
Laura F Landweber Birth and Evolution of Human Exons
Maria Dulcetti Vibranovski
Noboru Jo Sakabe
Manyuan Long Exons and Protein Modules
László Patthy Insertion and Deletion of Exons During Human Gene Evolution
David N Cooper Exons: Shuffling
László Patthy Pseudoexons
Manyuan Long Domain Duplication and Gene Elongation
Wen-Hsiung Li
Kateryna D Makova The Contribution of Frameshift Translation to the Generation of Novel Human Proteins
Kohji Okamura
Stephen W Scherer Transposable Element-driven Duplications during Hominoid Genome Evolution
Bud Mishra The Contribution of Transposable Elements to Human Proteins
Jean-Nicolas Volff Evolutionary Emergence of Genes Through Retrotransposition
Richard Cordaux
Mark A Batzer Multigene Families: Evolution
J Bruce Walsh
Wolfgang Stephan Paralogous Genes and Chromosomal Regions
Lars-Gustav Lundin
Dan Larhammar
Finn Hallböök Bi-directional Gene Pairs in the Human Genome
Kanako O Koyanagi
Tadashi Imanishi
Takashi Gojobori Gene Fusion
Esther Betrán Protein Families: Evolution
Richard R Copley Fibroblast Growth Factors: Evolution
David M Ornitz Globin Genes: Evolution
Ross C HardisonHox Genes and Body Plan: Evolution
Ella Tour
William McGinnisPax Genes: Evolution and Function
Maxime Bouchard
Alexander Schleiffer
Frank Eisenhaber
Meinrad Busslinger Low-density Lipoprotein Receptor (LDLR) Family: Genetics and Evolution
Wolfgang Johann Schneider Major Histocompatibility Complex (MHC) Genes: Evolution
Austin L Hughes Major Histocompatibility Complex (MHC) Genes: Polymorphism
Diogo Meyer
Steven J Mack Vertebrate Immune System: Evolution
Austin L Hughes Evolution of the Human Immune System
Nadia Danilova Complement System: Evolution
Masaru Nonaka Somatic Hypermutation of Antigen Receptor Genes: Evolution
Marilyn Diaz
Laurent K Verkoczy Neuropeptides and their Receptors: Evolution
Charles HV Hoyle Nuclear Receptor Genes: Evolution
Gareth I Owen Olfactory Receptor Genes: Evolution
Yoshihito Niimura Visual Pigment Genes: Evolution
Shozo Yokoyama Bitter Taste Sensitivity in Humans and Chimpanzees
Maik Behrens
Wolfgang Meyerhof Evolution of Skin Pigmentation Differences in Humans
Heather Norton Population Genetics of Lactase Persistence and Lactose Intolerance
Catherine Janet Ellen Ingram
Dallas Mary Swallow Defensins: Evolution
Austin L Hughes Cystic Fibrosis Transmembrane Conductance Regulator Sequences: Comparative Analysis
Jian-Min Chen
Guillaume Lecointre
Erick Denamur
Claude Férec ATP-binding Cassette (ABC) Transporter Supergene Family: Genetics and Evolution
Michael Dean Proteases: Evolution
Christopher Southan Serpins: Evolution
Gary A Silverman
David J Askew
James A Irving
Cliff J Luke
Dion Kaiserman
Phillip I Bird
James C Whisstock Adaptive Evolution of Primate Sperm Proteins
Nathaniel L Clark Drug Metabolism: Evolution
Daniel W Nebert rRNA Genes: Evolution
Iris L Gonzalez
James E Sylvester MicroRNA Evolution in the Human Genome
Bing Su
Rui Zhang Pseudogene Evolution in the Human Genome
Zhaolei Zhang
Deyou Zheng Human Lineage-specific Gene Inactivation
Wendy E Grus
Jianzhi Zhang Pseudogenes: Age
Allen R Rhoads
Felix Friedberg Pseudogenes: Patterns of Mutation
Francesc Calafell
Jaume Bertranpetit Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes
Hiroaki
Takeshi Itoh
Takashi GojoboriEvolution of Gene Expression Transcriptional Regulation: Evolution
Gregory A Wray Promoters: Evolution
Deborah L Gumucio Evolution of Human Gene Expression Control
Courtney C Babbitt
Gregory A Wray Positive Selection and the Evolution of Prodynorphin
Matthew V Rockman Human Transcriptome Evolution
Xun Gu
Yong Huang Evolution of Gene Expression in Human and Chimpanzee Brains
Naoki Osada
Sugano Sumio
Yutaka Suzuki Human and Chimpanzee Transcriptomes: Comparative Evolution
Philipp Khaitovich
David Cooper
Hildegard Kehrer-Sawatzki Human and Macaque Transcriptiomes: A comparison
Stephen J Walker Transcription Factor-binding Sites: Recent Evolution in the Human Lineage
Berthold Göttgens Alternative Polyadenylation in the Human Genome: Evolution
Bin TianMitochondrial Genome Evolution Mitochondrial Genome: Evolution
Mark Stoneking Mitochondrial Non-Mendelian Inheritance: Evolutionary Origin and Consequences
C William Birky Jr Mitochondrial Genome Sequences and Their Phylogeographic Interpretation
Vincent Macaulay
Martin Richards Mitochondrial Origins of Human Nuclear Genes and DNA Sequences
William F MartinChromosomal Evolution Chromosomes in Mammals: Diversity and Evolution
Johannes Wienberg
Stefan Müller Chromosome Numbers in Mammals
Harry Scherthan Chromosome Rearrangement Patterns in Mammalian Evolution
Johannes Wienberg
Stefan Müller Hotspots of Mammalian Chromosome Evolution
Lutz Froenicke
Leslie A Lyons Chromosomal Rearrangements in Primates
Roscoe Stanyon
Francesca Bigoni Chromosomal Rearrangements in the Human and Chimpanzee Lineages
Hildegard Kehrer-Sawatzki
David N Cooper Human Chromosome Evolution
Gerald P Holmquist
Johannes Wienberg Polyploid Origin of the Human Genome
Masanori Kasahara Chromatin Structure and Human Genome Evolution
Colin AM Semple Mammalian Sex Chromosome Evolution
Gerald J
Christine M Malcom Evolution of the Mammalian X Chromosome
Paul D Waters
Terence J Robinson Y Chromosome Evolution
Vladimir A Gvozdev X and Y Chromosomes: Homologous Regions
Nisrine El-Moghabel
Jennifer A M Graves Evolution of Common Fragile Sites
Anne HelmrichComparative Genomics Comparative Cytogenetics
Matthew Breen
Cordelia Langford Comparative Cytogenetics Technologies
Stefan Müller
Johannes Wienberg Reconstruction of Ancestral Genomes
Roscoe Stanyon
Fiorella Garofalo
Francesca Bigoni Comparative Human Genomics
I King Jordan
Eugene V Koonin Orthologues, Paralogues and Xenologues in Human and Other Genomes
Olga Zhaxybayeva
J Peter Gogarten
R Andrew Cameron Comparing the Human and Fish Genomes
Yoichiro Nakatani
Shinichi Morishita Comparing the Human and Medaka Genomes
Takashi Sasaki
Nobuyoshi
B Venkatesh The Mouse Genome as a Rodent Model in Evolutionary Studies
Jessica Vamathevan
Joanna D Holbrook
Richard D Emes The Rat Genome as a Rodent Model in Evolutionary Studies
Kim Fechtel Comparing the Human and Canine Genomes
Marek Switonski
Izabela Szczerbal Primate Phylogenetics
Todd R Disotell The Sequencing of the Rhesus Macaque Genome and its Comparison with the Genome Sequences of Human and Chimpanzee
Richard A Gibbs
Kim C Worley
Hildegard Kehrer-Sawatzki
David N Cooper The Chimpanzee Genome Project
David N Cooper
Hildegard Kehrer-Sawatzki Comparing the Human and Chimpanzee Genomes
Monica Uddin
Derek E Wildman
Morris Goodman Nucleotide Sequence Divergence between Humans and Chimpanzees
Feng-Chi Chen
Trees-Juen Chuang Human-specific Changes of Genome Structure
R Alan Harris
Aleksandar MilosavljevicEvolution and Disease Susceptibility Evolutionary Thinking in the Medical Sciences
Stephen C Stearns Darwinian Medicine
George C Williams Pathological Missense Mutations Provide New Insights into the Evolution of Trypsinogen Genes
Jian-Min Chen
David N Cooper
Claude Férec Balancing Selection in Human Evolution
Eric J Vallender
Welkin E Johnson Selective Constraints on Human Disease Mutations and Polymorphisms
Hernán Dopazo Genetic of Large Populations and Association Studies
Pauline Hélène Garnier-Géré
Lounès Chikhi Genetic Disease in the Ashkenazim: Role of a Founder Effect
Inbal Kedar-Barnes
Paul Rozen
Mordechai Shohat
Hagit N Baris Single Nucleotide Polymorphisms in Human Disease and Evolution: Phylogenies and Genealogies
Paul D Thomas Structural Diversity of the Human Genome and Disease Susceptibility
Richard S Smith
María Gutiérrez-Arcelus
Charles W Tran
Stephanie Park
Cheryn J Couter
Charles Lee Segmental Duplications and Genetic Disease
Beverly S Emanuel
Tamim H Shaikh Genetics of Susceptibility to Human Infectious Diseases
Richard A Kaslow
Sadeep Shrestha
Jianming `James' Tang The Genetics of Malarial Resistance and Susceptibility
Brian C Verrelli The Evolution of Fatness and Susceptibility to Obesity
Jonathan CK Wells Thrifty Genotype Hyphothesis and Complex Genetic Disease
Pnina Varidi
Konstantin Bloch An Evolutionary Framework for Common Disease
Francesca Luca
Anna Di Rienzo On Sequence Variants that Influence the Risk of Common Diseases
Kári Stefánsson
Jeffrey R Gulcher An Evolutionary Genetic Framework for Heritable Disorders
Matthew C KellerAnalysis of Ancient DNA Ancient DNA: Recovery and Analysis
Susanne Hummel Ancient DNA: Phylogenetic Applications
Michael Knapp
Linda Vigilant
Michael Hofreiter Neanderthal Mitochondrial DNA
William Goodwin
Igor Ovchinnikov Reconstructing Ancient DNA Sequences in Silico
Jian Ma
English
“The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin." (Genomic Medicine)
