In Vivo NMR Spectroscopy - Principles andTechniques 2e
Buy Rights Online Buy Rights

Rights Contact Login For More Details

More About This Title In Vivo NMR Spectroscopy - Principles andTechniques 2e


This is the second edition of a unique book in the field of in vivo NMR covering in detail the technical and biophysical aspects of the technique.

The contents of the book are appropriate to both beginners and experienced users of in vivo NMR spectroscopy. The new edition is focussed on bringing the reader practical insights and advice, but is also geared towards use as a study aid and in NMR courses. Recent advances in NMR spectroscopy, like high field NMR, hyperpolarized NMR and new localization and editing techniques have been included. An extensive and updated treatment of radiofrequency pulses is given, together with several tables and recipes for their generation.

Solutions to the exercises within this text can be found here


Robin A. de Graaf is the author of In Vivo NMR Spectroscopy: Principles and Techniques, 2nd Edition, published by Wiley.



List of Abbreviations and Symbols.

1Basic Principles.

1.1 Introduction.

1.2 Classical Description.

1.3 Quantum Mechanical Description.

1.4 Macroscopic Magnetization.

1.5 Excitation.

1.6 Bloch Equations.

1.7 Fourier Transform NMR.

1.8 Chemical Shift.

1.9 Digital Fourier Transform NMR.

1.10 Spin–spin Coupling.

1.11 T1 Relaxation.

1.12 T2 Relaxation and Spin-echoes.

1.13 Exercises.

References 41

2In VivoNMR Spectroscopy – Static Aspects.

2.1 Introduction.

2.2 Proton NMR Spectroscopy.

2.3 Phosphorus-31 NMR Spectroscopy.

2.4 Carbon-13 NMR Spectroscopy.

2.5 Sodium-23 and Potassium-39 NMR Spectroscopy.

2.6 Fluorine-19 NMR Spectroscopy.

2.7 Exercises.

3In VivoNMR Spectroscopy – Dynamic Aspects.

3.1 Introduction.

3.2 Relaxation.

3.3 Magnetization Transfer.

3.4 Diffusion.

3.5 Dynamic Carbon-13 NMR Spectroscopy.

3.6 Hyperpolarization.

3.7 Exercises.

4Magnetic Resonance Imaging.

4.1 Introduction.

4.2 Magnetic Field Gradients.

4.3 Slice Selection.

4.4 Frequency Encoding.

4.5 Phase Encoding.

4.6 Spatial Frequency Space.

4.7 Fast MRI Sequences.

4.8 Contrast in MRI.

4.9 Parallel MRI.

4.10 Exercises.

5Radiofrequency Pulses.

5.1 Introduction.

5.2 Square RF Pulses.

5.3 Selective RF Pulses.

5.4 Pulse Optimization.

5.5 DANTE RF Pulses.

5.6 Composite RF Pulses.

5.7 Adiabatic RF Pulses.

5.8 Pulse Imperfections and Relaxation.

5.9 Power Deposition.

5.10 Multidimensional RF Pulses.

5.11 Spectral–spatial RF Pulses.

5.12 Exercises.

6Single Volume Localization and Water Suppression.

6.1 Introduction.

6.2 Single Volume Localization.

6.3 Water Suppression.

6.4 Exercises.

7Spectroscopic Imaging and Multivolume Localization.

7.1 Introduction.

7.2 Principles of Spectroscopic Imaging.

7.3 Spatial Resolution in MRSI.

7.4 Temporal Resolution in MRSI.

7.5 Lipid Suppression.

7.6 Spectroscopic Imaging Processing and Display.

7.7 Multivolume Localization.

7.8 Exercises.

8Spectral Editing and Two-dimensional NMR.

8.1 Introduction.

8.2 Scalar Evolution.

8.3 J-difference Editing.

8.4 Practical Considerations of J-difference Editing.

8.5 Multiple Quantum Coherence Editing.

8.6 Heteronuclear Spectral Editing.

8.7 Polarization Transfer – INEPT and DEPT.

8.8 Sensitivity.

8.9 Broadband Decoupling.

8.10 Two-dimensional NMR Spectroscopy.

8.10.1 Correlation Spectroscopy (COSY).

8.10.2 Spin-echo or J-resolved NMR.

8.10.3 Two-dimensional Exchange Spectroscopy.

8.11 Exercises.

9Spectral Quantification.

9.1 Introduction.

9.2 Data Acquisition.

9.3 Data Pre-processing.

9.4 Data Quantification.

9.5 Data Calibration.

9.6 Exercises.


10.1 Introduction.

10.2 Magnets.

10.3 Magnetic Field Homogeneity.

10.4 Magnetic Field Gradients.

10.5 Radiofrequency Coils.

10.6 Radiofrequency Coil Types.

10.7 Complete MR System.

10.8 Exercises.


A1 Matrix Calculations.

A2 Trigonometric Equations.

A3 Fourier Transformation.

A3.1 Introduction.

A3.2 Properties.

A3.3 Discrete Fourier Transformation.

A4 Product Operator Formalism.

A4.1 Cartesian Product Operators.

A4.2 Spherical Tensor Product Operators.


Further Reading.