Title Details

Editor-in-Chief:
Daniel K. Podolsky, M.D. President, Professor of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Associate Editors:
Michael Camilleri, M.D, Professor of Medicine and Physiology, College of Medicine, Mayo Clinic; Consultant in Gastroenterology, Mayo Clinic, Rochester.

J. Gregory Fitz, M.D, Dean, Southwestern Medical School, Distinguished Chair in Medical Science, UT Southwestern Medical Center, Dallas, TX, USA.

Anthony N. Kalloo, M.D, Professor of Gastroenterology and Director, Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, Baltimore, MD USA.

Fergus Shanahan, M.D, Professor and Chair, Department of Medicine and Director, Alimentary Pharmabiotic Centre, University College Cork, Cork University Hospital, Ireland.

Timothy C. Wang, M.D, Chief, Division of Digestive and Liver Diseases, Silberberg Professor Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY USA.

List of contributors ix

Preface xix

About the companion website xxi

PART 1 Anatomy and development

1 Esophagus: anatomy and structural anomalies 3
Ikuo Hirano

2 Stomach and duodenum: anatomy and structural anomalies 13
Eric Goldberg and Jean-Pierre Raufman

3 Small intestine: anatomy and structural anomalies 19
Deborah C. Rubin and Jacob C. Langer

4 Colon: anatomy and structural anomalies 24
Konstantin Umanskiy and Jeffrey B. Matthews

5 Pancreas: anatomy and structural anomalies 30
David G. Heidt, Michael W. Mulholland, and Diane M. Simeone

6 Abdominal cavity: anatomy, structural anomalies, and hernias 36
Kevin P. Murphy, Michael M. Maher, and Owen J. O’Connor

7 Gallbladder and biliary tract: anatomy and structural anomalies 43
Theodore H. Welling

8 Liver: anatomy, microscopic structure, and cell types, 50
Gary C. Kanel

PART 2 Gastrointestinal diseases

A Esophagus

9 Motility disorders of the esophagus 61
Joan W. Chen, John E. Pandolfino, and Peter J. Kahrilas

10 Gastroesophageal reflux disease 72
Kumar Krishnan, John E. Pandolfino, and Peter J. Kahrilas

11 Eosinophilic esophagitis 82
Yael Haberman Ziv, Margaret H. Collins, and Marc E. Rothenberg

12 Esophageal infections and disorders associated with acquired immunodeficiency syndrome 85
C. Mel Wilcox

13 Esophageal neoplasms 93
Adam J. Bass and Anil K. Rustgi

14 Miscellaneous diseases of the esophagus: foreign bodies, physical injury, and systemic and dermatological diseases 102
Seth D. Crockett, Evan S. Dellon, and Nicholas J. Shaheen

B Stomach

15 Disorders of gastric emptying 115
Henry P. Parkman

16 Peptic ulcer disease 124
Jonathan R. White, Krish Ragunath, and John C. Atherton

17 Zollinger–Ellison syndrome 135
Robert T. Jensen

18 Gastritis and gastropathy 140
David Y. Graham and Robert M. Genta

19 Tumors of the stomach 149
Emad M. El-Omar and Chun-Ying Wu

20 Miscellaneous diseases of the stomach 153
Tamas A. Gonda and Yanghee Woo

C Small intestine

21 Dysmotility of the small intestine and colon 157
Michael Camilleri, Silvia Delgado-Aros, and Lawrence Szarka

22 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections 170
Gail A. Hecht, Jerrold R. Turner, and Phillip I. Tarr

23 Chronic infections of the small intestine 177
George T. Fantry, Lori E. Fantry, Stephen P. James, and David H. Alpers

24 Disorders of epithelial transport, metabolism, and digestion in the small intestine 184
Richard J. Grand

25 Short bowel syndrome 189
Richard N. Fedorak, Leah M. Gramlich, and Lana Bistritz

26 Tumors of the small intestine 202
Barbara H. Jung and Maria Rosario Ferreira

27 Miscellaneous diseases of the small intestine 208
Marc S. Levin

D Inflammatory Bowel Disease

28 Ulcerative colitis: clinical manifestations and management 216
William F. Stenson, William J. Tremaine, and Russell D. Cohen

29 Crohn’s disease: clinical manifestations and management 225
Gil Y. Melmed and Stephan R. Targan

E Colon

30 Polyps of the colon and rectum 234

Daniel C. Chung and John J. Garber III

31 Malignant tumors of the colon 238
Jay Luther and Andrew T. Chan

32 Polyposis syndromes 246
Randall W. Burt, Mary P. Bronner, and Kory W. Jasperson

33 Colorectal cancer screening 266
Uri Ladabaum

34 Anorectal diseases 270
Adil E. Bharucha and Arnold Wald

F Pancreas

35 Acute pancreatitis 287
Hana Algül and Roland M. Schmid II

36 Chronic pancreatitis 307
Joachim Mössner, Albrecht Hoffmeister, and Julia Mayerle

37 Hereditary diseases of the pancreas 317
Carlos G. Micames and Jonathan A. Cohn

38 Cystic lesions of the pancreas 324
James J. Farrell

39 Neuroendocrine tumors of the pancreas 329
Peter J. Carolan and Daniel C. Chung

G Gallbladder and biliary tract

40 Gallstones 335
Piero Portincasa and David Q.-H. Wang

41 Primary sclerosing cholangitis and other cholangiopathies 354
Russell H. Wiesner and Kymberly D.S. Watt

42 Cystic diseases of the liver and biliary tract 361
James L. Buxbaum and Shelly C. Lu

43 Tumors of the biliary tract 368
Tushar Patel

H Liver

44 Acute viral hepatitis 374
Marc G. Ghany and T. Jake Liang

45 Chronic hepatitis B viral infection 387
Robert G. Gish

46 Hepatitis C virus infection 392
Raymond T. Chung and Andrew Tai

47 Drug-induced liver disease 397
Frank V. Schiødt and William M. Lee

48 Autoimmune hepatitis 405
Richard Taubert and Michael P. Manns

49 Primary biliary cirrhosis 409
Marlyn J. Mayo and Dwain L. Thiele

50 Hemochromatosis 415
Paul C. Adams

51 Metabolic diseases of the liver 419
Ronald J. Sokol and Mark A. Lovell

52 Alcoholic liver disease 423
Jose Altamirano, Eric S. Orman, and Ramon Bataller,

53 Nonalcoholic fatty liver disease 428
M. Shadab Siddiqui and Arun J. Sanyal

54 Hepatic fibrosis 436
Don C. Rockey

55 Approach to the patient with ascites and its complications 447
Guadalupe Garcia-Tsao

56 Liver transplantation 459
Alyson N. Fox and Robert S. Brown, Jr.

57 Hepatocellular carcinoma 465
Jorge A. Marrero and Amit Singal

58 Liver abscess 469
Roman E. Perri and David S. Raiford

59 Vascular diseases of the liver 472
Susana Seijo and Laurie D. DeLeve

I Miscellaneous

60 Intraabdominal abscesses and fistulae 477
Peter Irving and Nyree Griffin

61 Diseases of the peritoneum, retroperitoneum, mesentery, and omentum 484
Jennifer W. Harris, Scott D. Stevens, and B. Mark Evers

62 Obesity: treatment and complications 491
Louis A. Chaptini and Steven Peikin

63 Bariatric surgery and complications 495
Obos Ekhaese, Danny O. Jacobs, and Russell LaForte

64 Complications of AIDS and other immunodeficiency states, 501
Phillip D. Smith, Nirag C. Jhala, C. Mel Wilcox, and Edward N. Janoff

65 Gastrointestinal manifestations of immunological disorders, 509
Paula O’Leary and Fergus Shanahan

66 Parasitic diseases: protozoa, 515
Ellen Li and Samuel L. Stanley Jr.

67 Helminthic infections of the gastrointestinal tract and liver, 524
Thormika Keo, John Leung, and Joel V. Weinstock

68 Gastrointestinal manifestations of systemic diseases, 544
Eran Israeli and Charles N. Bernstein

69 Skin lesions associated with gastrointestinal and liver diseases, 554
Kim B. Yancey and Travis W. Vandergriff

70 Oral manifestation of gastrointestinal diseases, 574
Vidyasagar Ramappa and Yashwant R. Mahida

71 Intestinal ischemia and vasculitides, 582
Juan-Ramón Malagelada and Carolina Malagelada

72 Radiation injury in the gastrointestinal tract, 597
Steven M. Cohn and Stephen J. Bickston

PART 3 Diagnostic and therapeutic modalities in gastroenterology

A Endoscopic

73 Upper gastrointestinal endoscopy 605
Ebubekir S. Daglilar, Abdurrahman Kadayifci, and William R. Brugge

74 Capsule and small bowel endoscopy 621
Jonathan A. Leighton and Shabana F. Pasha

75 Colonoscopy and flexible sigmoidoscopy 626
Peter H. Rubin, Steven Naymagon, Christopher B. Williams, and Jerome D. Waye

76 Endoscopic retrograde cholangiopancreatography: diagnostic and therapeutic 634
Mustafa A. Arain and Martin L. Freeman

77 Gastrointestinal dilation and stent placement 643
Shayan Irani and Richard A. Kozarek

78 Management of upper gastrointestinal hemorrhage related to portal hypertension
Tinsay A. Woreta and Zhiping Li

79 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhage 675
David J. Bjorkman

80 Endoscopic therapy for polyps and tumors 680
Mouen A. Khashab, Sergey V. Kantsevoy, and Heiko Pohl

81 Laparoscopy and laparotomy 698
Ricardo Zorron and Gustavo Carvalho

82 Natural orifice translumenal endoscopic surgery (NOTES) 702
Vivek Kumbhari and Anthony N. Kalloo

B Imaging

83 Plain and contrast radiology 722
Marc S. Levine and Stephen E. Rubesin

84 Transabdominal sonography 732
Stephanie F. Coquia, Linda C. Chu, and Ulrike M. Hamper

85 Endoscopic ultrasonography 741
Marcia Irene Canto and Mouen A. Khashab

86 Computed tomography of the gastrointestinal tract 756
Siva P. Raman, Karen M. Horton, Pamela T. Johnson, and Elliot K. Fishman

87 Magnetic resonance imaging 768
Diane Bergin

88 Positron emission tomography in the gastrointestinal tract 782
Manuela Matesan, Jonathan Sham, James Park, and Satoshi Minoshima

89 Radionuclide imaging of the gastrointestinal tract 804
Harvey A. Ziessman

90 Abdominal angiography 820
Kyung Jae Cho

91 Interventional radiology 842
Todd R. Schlachter, Julius Chapiro, Rafael Duran, Vania Tacher, Camila Zamboni, Luke Higgins, and Jean-Francois Henri Geschwind

C Pathology

92 Liver biopsy and histopathological diagnosis 860
Sugantha Govindarajan

93 Endoscopic mucosal biopsy: histopathological interpretation 878
Elizabeth Montgomery and Anthony N. Kalloo

Index 931