C-H Activation for Asymmetric Synthesis
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More About This Title C-H Activation for Asymmetric Synthesis
English
C-H activation in asymmetric synthesis is one of the most rapidly developing fields in organic chemistry. It opens a new way for accessing optive active compounds in an easy and effective way. This book presents this exciting field with all its facets.
English
Françoise Colobert is director of the chemistry department of the Chemistry engineering High School ECPM at the University of Strasbourg. She received a Ph.D. in organic chemistry in 1985 from the University Pierre et Marie Curie (Paris, France) working with Prof. Jean-Pierre Genêt. After a post-doctoral position in the group of Prof. Jules Hoffman in molecular biology, Françoise Colobert became an assistant professor in the group of Prof. Guy Solladié (University Louis Pasteur, Strasbourg) and obtained her habilitation (HDR) in 1999. She was appointed full professor of organic chemistry in 2001.
Her current research interests are oriented towards homogeneous catalysis, in particular C-H activation directed by sulfoxides, C-C asymmetric biaryl coupling by Suzuki-Miyaura and aryne couplings or by C-H activation; the synthesis of new biaryl ligands for asymmetric catalysis and the total synthesis of biologically active molecules.
Joanna Wencel-Delord was educated in chemistry at the Ecole Nationale Supérieure de Chimie de Rennes, France and she received her PhD in 2010 from the University of Rennes 1, France (Dr. C. Crévisy and Dr. M. Mauduit). After postdoctoral studies with Prof. F. Glorius at the Westfälische Wilhelms-Universität Münster (Germany) and temporary assistant professor position (ATER) at the University of Strasbourg (Prof. P. Compain), she joined in 2013 CNRS as associate researcher in the group of Prof. F. Colobert (University of Strasbourg, France). Her research focuses on the transition metal-catalyzed asymmetric C-H activation.
Her current research interests are oriented towards homogeneous catalysis, in particular C-H activation directed by sulfoxides, C-C asymmetric biaryl coupling by Suzuki-Miyaura and aryne couplings or by C-H activation; the synthesis of new biaryl ligands for asymmetric catalysis and the total synthesis of biologically active molecules.
Joanna Wencel-Delord was educated in chemistry at the Ecole Nationale Supérieure de Chimie de Rennes, France and she received her PhD in 2010 from the University of Rennes 1, France (Dr. C. Crévisy and Dr. M. Mauduit). After postdoctoral studies with Prof. F. Glorius at the Westfälische Wilhelms-Universität Münster (Germany) and temporary assistant professor position (ATER) at the University of Strasbourg (Prof. P. Compain), she joined in 2013 CNRS as associate researcher in the group of Prof. F. Colobert (University of Strasbourg, France). Her research focuses on the transition metal-catalyzed asymmetric C-H activation.
English
Asymmetric activation of C(sp3)-H bonds
-C(sp3)-H bond insertion by metal carbenoids and nitrenoids
- Stereoselective C-C Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
- Stereoselective C-N Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
C(sp3)-H activation as stereodiscriminant step
- Enantioselective Intra- and intermolecular couplings
- Substrat-controlled transformation ? diastereoselective functionalization
Stereoselective synthesis implying activation of C(sp2)-H bonds
C-H activation involved in stereodiscriminant step
-Planar chirality
-Stereoselective synthesis implying activation of C(sp2)-H bonds-Control of axial chirality
-Central chirality via Asymmetric C(sp2)-H activation implying Desymmetrization and kinetic resolution
Non-stereoselective C-H activation followed by selective functionalization of metallacyclic intermediate
Diastereoselective Formation of Alkenes through C(sp2)?H Bond Activation
-C(sp3)-H bond insertion by metal carbenoids and nitrenoids
- Stereoselective C-C Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
- Stereoselective C-N Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
C(sp3)-H activation as stereodiscriminant step
- Enantioselective Intra- and intermolecular couplings
- Substrat-controlled transformation ? diastereoselective functionalization
Stereoselective synthesis implying activation of C(sp2)-H bonds
C-H activation involved in stereodiscriminant step
-Planar chirality
-Stereoselective synthesis implying activation of C(sp2)-H bonds-Control of axial chirality
-Central chirality via Asymmetric C(sp2)-H activation implying Desymmetrization and kinetic resolution
Non-stereoselective C-H activation followed by selective functionalization of metallacyclic intermediate
Diastereoselective Formation of Alkenes through C(sp2)?H Bond Activation
