Title Details

Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation
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More About This Title Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation

  • English

English

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.

  • Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research
  • Includes detailed presentations of study methodology and data collection, analysis, and interpretation
  • Discusses tools like experimental design, sample handling, analytical measurement techniques
  • English

English

JONATHAN W. BOYD, PHD, is an Associate Professor in the Department of Orthopaedics at West Virginia University School of Medicine.

RICHARD R. NEUBIG, MD, PHD, is Chair and Professor in the Department of Pharmacology and Toxicology at Michigan State University.

  • English

English

List of Contributors

About the Editors

Preface

Chapter 1: Introduction to cellular signal transduction: The connection between a biological system and its surroundings
Jonathan Boyd, Richard Neubig, Alice Han, Maren Prediger

Chapter 2: Mechanisms of cellular signal transduction
Richard Neubig, Jonathan Boyd, Julia Mouch, Nicole Prince

Chapter 3: From cellular mechanisms to physiological responses: Functional signal integration across multiple biological levels
Robert Newman

Chapter 4: Signal transduction in disease: Relating cell signaling to morbidity and mortality
Patricia E. Ganey, Sean E. Misek

Chapter 5: Experimental design in signal transduction
Weimin Gao, Meghan Cromie, Qian Wang, Zhongwei Liu, Song Tang, Julie Miller

Chapter 6: Techniques for measuring cellular signal transduction
Julie Miller, Weimin Gao, Meghan Cromie

Chapter 7: Computational methods for signal transduction: A network approach
Giovanni Scardoni, Gabriele Tosadori, John Morris, A. Pegoraro, Sakshi Pratap, Carlo Laudanna, Alice Han

Chapter 8: A toxicological application of signal transduction: Early cellular changes can be indicative of toxicity
Julie Miller, Nicole Prince, Julia Mouch, Jonathan Boyd 

Chapter 9: Future research in signaling 
Jonathan Boyd, Nicole Prince

Index

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