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More About This Title Direct Lineage Reprogramming: From Fundamental Biology to Brain Repair
English
Recent advances in cell biology have allowed researchers to breakdown the barrier between cell types. This has unlocked the potential of converting somatic cells into pluripotent stem cells, introducing a valuable new tool to basic science and biomedical researchers. Neuroscientists are now rapidly adopting these technologies to better understand neurophysiology and the development of disease. Neural Cell Reprogramming provides a timely overview and synthesis of this work.
Neural Cell Reprogramming opens with chapters that introduce the basic concepts of cellular reprogramming and the application of these technologies to neuronal cells. Coverage then explores advances in the field and the potential application of reprogramming technologies in fields ranging from basic neuroscience research into drug discovery and the development of novel therapeutics. The book closes with a valuable chapter exploring the ethical questions and issues surrounding the use of reprogrammed cells in research.
A timely and valuable volume, Neural Cell Reprogramming is an essential book for anyone working in the fields of neuroscience, stem cell biology, and neurotherapuetics.
English
- Introduction: The concept of cellular reprogramming (Berninger)
- Reprogramming somatic cells into pluripotent stem cells as a source for neural cells (Hynek Wichterle, Kevin Eggan, Lorenz Studer)
- Direct reprogramming of somatic cells into neural cells (Marius Wernig)
- Studying cortical histogenesis using induced pluripotent stem cells (Frederick Livesey, Pierre Vanderhaeghen)
- Modeling human neurological disease by reprogramming patient-derived somatic cells (Oliver Brüstle, Elena Cattaneo)
- Perspectives of improving reprogramming safety and efficiency (Frank Edenhofer)
- Utilizing human induced pluripotent stem cells for drug development (Roberto Iacone, F. Hoffmann-La Roche, Basel, Stem Cell Platform)
- The transcriptional control of neurogenesis (Diogo Castro, Francois Guillemot)
- The impact of the epigenome on neural differentiation and reprogramming (Noel Buckley, Vijay Tiwari, Raymond Poot)
- Deriving midbrain dopaminergic neurons by direct reprogramming (Vania Broccoli, Malin Parmar)
- Direct conversion of brain resident cells into induced neuronal cells (Karow and Berninger)
- Lessons learnt from organisms capable of nervous tissue regeneration (Michael Brand, Daniel Goldman, Thomas Reh)
- Studying direct in vivo reprogramming using the model organism C. elegans (Baris Tursun, Oliver Hobert)
- Programming and reprogramming the nervous system: the example of Fezf2 (Paola Arlotta, Caroline Rouaux)
- The challenge of functional integration into a pre-existing network (Matteo Bergami, Chichung Lie, Alejandro Schinder, Angelique Bordey)
- On the ethics of reprogramming(Demetrio Neri)
