Title Details

Editor-in-Chief:

Daniel K. Podolsky, M.D. President, Professor of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Associate Editors:
Michael Camilleri, M.D, Professor of Medicine and Physiology, College of Medicine, Mayo Clinic; Consultant in Gastroenterology, Mayo Clinic, Rochester.

J. Gregory Fitz, M.D, Dean, Southwestern Medical School, Distinguished Chair in Medical Science, UT Southwestern Medical Center, Dallas, TX, USA.

Anthony N. Kalloo, M.D, Professor of Gastroenterology and Director, Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, Baltimore, MD USA.

Fergus Shanahan, M.D, Professor and Chair, Department of Medicine and Director, Alimentary Pharmabiotic Centre, University College Cork, Cork University Hospital, Ireland.

Timothy C. Wang, M.D, Chief, Division of Digestive and Liver Diseases, Silberberg Professor Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY USA.

Contributors

Preface

Foreword by Tadataka Yamada

About the companion website and companion digital edition

VOLUME ONE

PART 1, Anatomy and development

1 Development and diff erentiation of the gastrointestinal system
Ben Z. Stanger and Daniel K. Podolsky

2 Stem cells and tissue renewal
Johan H. van Es, Sina Bartfeld, and Hans Clevers

3 Esophagus: anatomy and structural anomalies
Ikuo Hirano

4 Stomach and duodenum: anatomy and structural anomalies
Eric Goldberg and Jean-Pierre Raufman

5 Small intestine: anatomy and structural anomalies
Deborah C. Rubin and Anisa Shaker

6 Colon: anatomy and structural anomalies
Konstantin Umanskiy and Jeffrey B. Matthews

7 Pancreas: anatomy and structural anomalies
Kevin Tri Nguyen and Diane M. Simeone

8 Abdominal cavity: anatomy, structural anomalies, and hernias
Kevin P. Murphy, Michael M. Maher, and Owen J. O’Connor

9 Gallbladder and biliary tract: anatomy and structural anomalies
Theodore H. Welling

10 Liver: anatomy, microscopic structure, and cell types
Gary C. Kanel

11 Gastrointestinal blood flow
Thörsten Vowinkel and D. Neil Granger

PART 2, Mechanisms of normal and abnormal gastrointestinal function

A Components

12 Integrative responses of the gastrointestinal tract, pancreas, and liver to a meal
Stephen J. Pandol, Helen E. Raybould, and Hal Yee

13 Gastrointestinal hormones and receptors
Laurence J. Miller

14 The brain–gut axis
Adam D. Farmer and Qasim Aziz

15 The innervation of the gastrointestinal tract
John B. Furness, Daniel P. Poole, Hyun-Jung Cho, Brid P. Callaghan, and Leni R. Rivera

16 Smooth muscle of the gut
Gabriel M. Makhlouf and Karnam S. Murthy

17 The mucosal immune system and gastrointestinal inflammation
Fabio Cominelli, Kristen O. Arseneau, Matthew J. Hamilton, and Richard S. Blumberg

18 Epithelia and gastrointestinal function
Jerrold R. Turner

B Motility

19 Esophageal motor function
Peter J. Kahrilas, John E. Pandolfino, and David A. Katzka

20 Gastric motility and gastric emptying
Michael Camilleri

21 Motility of the small intestine and colon
Adil E. Bharucha and William Lee Hasler

22 Motility of the biliary tract
Gary M. Mawe, Brigitte Lavoie, Peter L. Moses, and Maria J. Pozo

C Secretion and absorption

23 Gastric secretions
M. Michael Wolfe and Robert C. Lowe

24 Electrolyte secretion and absorption in the small intestine and colon
Kim E. Barrett and Stephen J. Keely

25 Pancreatic secretion
Chung Owyang and John A. Williams

26 Bile secretion and cholestasis
Andrew P. Feranchak

D Nutrition

27 General nutritional principles
David H. Alpers and Kevin D. Cashman

28 Control of appetite/satiety and energy balance
Joel K. Elmquist and Jay D. Horton

29 Nutrient digestion, absorption, and sensing
Shrinivas Bishu and Eamonn M.M. Quigley

30 Vitamins and minerals
Francis C. Okeke, Danielle Flug Capalino, Laura E. Matarese, and Gerard E. Mullin

E Miscellaneous

31 Neoplasia of the gastrointestinal tract
Ofer Margalit and Raymond N. DuBois

32 The human intestinal microbiota and microbiome
Omry Koren and Ruth E. Ley

33 Drug metabolism, transport, and pharmacogenomics
Kristina K. Wolf, Brandon T. Gufford, Scott J. Brantley, Paul B. Watkins, and Mary F. Paine

PART 3, Principles of clinical gastroenterology

34 Clinical decision making
Jasmine K. Zia and John M. Inadomi

35 Approach to the patient with dyspepsia and related functional gastrointestinal complaints
Jan F. Tack

36 Approach to the patient with dysphagia, odynophagia, or noncardiac chest pain
André J.P.M. Smout

37 Approach to the patient with unintentional weight loss
Sreedhar Subramanian and Jonathan M. Rhodes

38 Approach to the patient with nausea and vomiting
William Lee Hasler

39 Approach to the patient with abdominal pain
Pankaj J. Pasricha

40 Approach to the patient with gas and bloating
Satish S.C. Rao and Yeong Yeh Lee

41 Approach to the patient with diarrhea
Gail A. Hecht, Jonathan Gaspar, and Miguel Malespin

42 Approach to the patient with constipation
Satish S.C. Rao and Michael Camilleri

43 Approach to the patient with acute abdomen
Courtney B. Sherman and Kenneth McQuaid

44 Approach to the patient with gastrointestinal bleeding
Kevin A. Ghassemi and Dennis M. Jensen

45 Approach to the patient with abnormal liver chemistries or jaundice
J. Gregory Fitz

46 Approach to gastrointestinal and liver diseases in pregnancy
Sumona Saha and Nancy Reau

47 Genetic counselling for gastrointestinal patients
Laura E. Panos and C. Richard Boland

PART 4, Gastrointestinal diseases

A Esophagus

48 Motility disorders of the esophagus
John E. Pandolfi no and Peter J. Kahrilas

49 Gastroesophageal reflux disease
Sabine Roman, John E. Pandolfino, and Peter J. Kahrilas

50 Eosinophilic esophagitis
Yael Haberman Ziv, Margaret H. Collins, and Marc E. Rothenberg

51 Esophageal infections and disorders associated with acquired immunodeficiency syndrome
C. Mel Wilcox

52 Barrett esophagus and esophageal adenocarcinoma
Stuart Jon Spechler, David H. Wang, and Rhonda F. Souza

53 Esophageal squamous cell carcinomas and other neoplasms
Adam J. Bass and Anil K. Rustgi

54 Miscellaneous diseases of the esophagus: foreign bodies, physical injury, and systemic and dermatological diseases
Seth D. Crockett, Evan S. Dellon, and Nicholas J. Shaheen

B Stomach

55 Disorders of gastric emptying
Henry P. Parkman

56 Peptic ulcer disease
Richard J.M. Ingram, Krish Ragunath, and John C. Atherton

57 Zollinger–Ellison syndrome
Robert T. Jensen

58 Gastritis and gastropathy
Mary Kay Washington and Richard M. Peek Jr.

59 Tumors of the stomach
Emad M. El-Omar and Mairi H. McLean

60 Miscellaneous diseases of the stomach
Tamas A. Gonda and Yanghee Woo

C Small intestine

61 Dysmotility of the small intestine and colon
Lawrence Szarka

62 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections
Mitchell B. Cohen

63 Chronic infections of the small intestine
Billy Bourke and Séamus Hussey

64 Celiac disease
Daniel A. Leffl er, Melinda Dennis, and Ciarán P. Kelly

65 Disorders of epithelial transport, metabolism, and digestion in the small intestine
Sushila R. Dalal and Eugene B. Chang

66 Bacterial overgrowth
Eamonn M.M. Quigley

67 Short bowel syndrome and small bowel transplantation
John K. DiBaise and Debra Sudan

68 Tumors of the small intestine
Maria Rosario Ferreira and Barbara H. Jung

69 Miscellaneous diseases of the small intestine
Marc S. Levin

D Inflammatory bowel disease

70 Inflammatory bowel diseases: pathogenesis
Ashwin N. Ananthakrishnan, Ramnik J. Xavier, and Daniel K. Podolsky

71 Ulcerative colitis
Stephen B. Hanauer and Daniel K. Podolsky

72 Crohn’s disease: clinical manifestations and management
Gil Y. Melmed and Stephan R. Targan

73 Surgical treatment of inflammatory bowel disease
Alessandro Fichera, Emily Finlayson, Leon Maggiori, and Fabrizio Michelassi

74 Microscopic colitis and other miscellaneous inflammatory and structural disorders of the colon
Eugene F. Yen and Darrell S. Pardi

E Colon

75 Irritable bowel syndrome
Elizabeth J. Videlock and Lin Chang

76 Diverticular disease of the colon
David J. Humes and Robin C. Spiller

Index

VOLUME TWO

77 Polyps of the colon and rectum
John J. Garber III and Daniel C. Chung

78 Malignant tumors of the colon
Jay Luther and Andrew T. Chan

79 Polyposis syndromes
Randall W. Burt and Kory W. Jasperson

80 Colorectal cancer screening
Uri Ladabaum

81 Anorectal diseases
Adil E. Bharucha and Arnold Wald

F Pancreas

82 Acute pancreatitis
Hana Algül, Andreas Weber, Wolfgang Huber, and Roland M. Schmid II

83 Autoimmune pancreatitis
Phil A. Hart and Suresh T. Chari

84 Chronic pancreatitis
Joachim Mössner, Albrecht Hoff meister, and Julia Mayerle

85 Hereditary diseases of the pancreas
David C. Whitcomb

86 Cystic lesions of the pancreas
James J. Farrell

87 Adenocarcinoma of the pancreas
Paul T. Fanta and Andrew M. Lowy

88 Neuroendocrine tumors of the pancreas
Peter J. Carolan and Daniel C. Chung

G Gallbladder and biliary tract

89 Gallstones
Piero Portincasa and David Q.-H. Wang

90 Primary sclerosing cholangitis
Jayant A. Talwalkar and Konstantinos N. Lazaridis

91 Cystic diseases of the liver and biliary tract
James Buxbaum and Shelly C. Lu

92 Tumors of the biliary tract
Tushar Patel

93 Sphincter of Oddi dysfunction and postcholecystectomy syndrome
John O. Clarke and Anthony N. Kalloo

H Liver

94 Acute viral hepatitis
Marc G. Ghany and T. Jake Liang

95 Chronic hepatitis B viral infection
Karin L. Andersson and Jules L. Dienstag

96 Hepatitis C virus infection
Andrew W. Tai and Raymond T. Chung

97 Drug-induced liver disease
William M. Lee

98 Acute liver failure
William M. Lee

99 Autoimmune hepatitis
Richard Taubert and Michael P. Manns

100 Primary biliary cirrhosis
Marlyn J. Mayo and Dwain L. Thiele

101 Hemochromatosis
Paul C. Adams

102 Metabolic diseases of the liver
Shikha S. Sundaram and Ronald J. Sokol

103 Alcoholic liver disease
Jose Altamirano, Eric S. Orman, and Ramon Bataller

104 Nonalcoholic fatty liver disease
M. Shadab Siddiqui and Arun J. Sanyal

105 Hepatic fi brosis and cirrhosis
Don C. Rockey

106 Ascites and its complications
Guadalupe Garcia-Tsao

107 Central nervous system and pulmonary complications of end-stage liver disease
Scott C. Matherly and Jasmohan S. Bajaj

108 Liver transplantation
Alyson N. Fox and Robert S. Brown Jr.

109 Hepatocellular carcinoma
Amit Singal and Jorge A. Marrero

110 Liver abscess
Roman E. Perri and David S. Raiford

111 Vascular diseases of the liver
Susana Seijo and Laurie D. DeLeve

I Miscellaneous

112 Intraabdominal abscesses and fistulae
Peter Irving and Nyree Griffin

113 Diseases of the peritoneum, retroperitoneum, mesentery, and omentum
Jennifer W. Harris and B. Mark Evers

114 Nutrition supplementation
Joshua D. Novak and Stephen J. D. O’Keefe

115 Obesity: treatment and complications
Louis A. Chaptini and Steven R. Peikin

116 Bariatric surgery
Obos Ekhaese and Danny O. Jacobs

117 Eating disorders
Henry C. Lin and Eric E. Stone

118 Complications of HIV/AIDS and other secondary immunodeficiencies
Phillip D. Smith and Edward N. Janoff

119 Immunological disorders: (a) Food allergy and hypersensitivity
Jonathan O’B. Hourihane

120 Immunological disorders: (b) immunodeficiencies and gastrointestinal complications of organ transplantation
Paula O’Leary and Fergus Shanahan

121 Parasitic diseases: protozoa
Ellen Li and Samuel L. Stanley Jr.

122 Parasitic diseases: helminths
Thormika Keo, John Leung, and Joel V. Weinstock

123 Gastrointestinal and hepatic manifestations of specific genetic disorders
Judy H. Cho

124 Gastrointestinal manifestations of systemic diseases
Eran Israeli and Charles N. Bernstein

125 Skin lesions associated with gastrointestinal and liver diseases
Travis W. Vandergriff and Kim B. Yancey

126 Oral manifestation of gastrointestinal diseases
Vidyasagar Ramappa and Yashwant R. Mahida

127 Gastrointestinal vascular malformations and neoplasms: arterial, venous, arteriovenous, and capillary
Anne C. Travis and Joshua R. Korzenik

128 Intestinal ischemia and vasculitides
Juan-Ramón Malagelada and Carolina Malagelada

129 Radiation injury in the gastrointestinal tract
Steven M. Cohn, Alda Vidrich, and Stephen J. Bickston

130 Complementary and alternative medicine in gastroenterology
Anthony Lembo and Andrea Bollom

PART 5, Diagnostic and therapeutic modalities in gastroenterology

A Endoscopic

131 General approach to endoscopy: sedation, monitoring, and preparation
Hala Fatima and Douglas K. Rex

132 Upper gastrointestinal endoscopy
Abdurrahman Kadayifci and William R. Brugge

133 Capsule and small bowel endoscopy
Jonathan A. Leighton and Shabana F. Pasha

134 Colonoscopy and flexible sigmoidoscopy
Peter H. Rubin, Steven Naymagon, Christopher B. Williams, and Jerome D. Waye

135 Endoscopic retrograde cholangiopancreatography
Mustafa A. Arain and Martin L. Freeman

136 Gastrointestinal dilation and stent placement
Shayan Irani and Richard A. Kozarek

137 Endoscopic approaches to enteral nutrition
Ryan J. Law and Todd H. Baron

138 Management of upper gastrointestinal haemorrhage related to portal hypertension
Tinsay A. Woreta and Zhiping Li

139 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhage
Anne Thai and Joseph W. Leung

140 Endoscopic therapy for polyps and tumors
Mouen A. Khashab and Heiko Pohl

141 Laparoscopy and laparotomy
Ricardo Zorron and Gustavo Carvalho

142 Submucosal endoscopy
Christopher J. Gostout

143 Natural orifice translumenal endoscopic surgery (NOTES)
Vivek Kumbhari and Anthony N. Kalloo

B Imaging

144 Plain and contrast radiology
Marc S. Levine and Stephen E. Rubesin

145 Abdominal sonography
Stephanie F. Coquia, Linda C. Chu, and Ulrike M. Hamper

146 Endoscopic ultrasonography
Mouen A. Khashab and Marcia Irene Canto

147 Computed tomography of the gastrointestinal tract
Siva P. Raman, Karen M. Horton, Pamela T. Johnson, Alec J. Megibow, and Elliot K. Fishman

148 Magnetic resonance imaging
Diane Bergin and Donald G. Mitchell

149 Positron emission tomography
Jonathan Sham, Manuela Matesan, James Park, and Satoshi Minoshima

150 Radionuclide imaging in the gastrointestinal tract
Harvey A. Ziessman

151 Abdominal angiography
Kyung Jae Cho

152 Interventional radiology
Todd R. Schlachter, Julius Chapiro, Rafael Duran, Vania Tacher, Camila Zamboni, Luke Higgins, and Jean-Francois Henri Geschwind

153 Confocal laser microscopy
Helmut Neumann and Ralf Kiesslich

C Pathology

154 Liver biopsy and histopathological diagnosis
Sugantha Govindarajan and Maurizio Bonacini

155 Endoscopic mucosal biopsy – histopathological interpretation
Elizabeth A. Montgomery and Anthony N. Kalloo

D Gastrointestinal function studies

156 Tests of gastric and pancreatic function and absorption
Joseph R. Pisegna and Deepinder Goyal

Index

"In short, this is an invaluable book, and a must for every gastroenterologist's practice. The content is exceptional, with detailed information on nearly all subspecialties in gastroenterology and quality images, including endoscopic pictures, for reference. Pairing the print version with the website is critical for keeping material relevant and accessible today. Dr. Yamada is a leader in the field of gastroenterology, and this book is an unparalleled contribution." (Doody Enterprises 15.03.2017)