Title Details

Offers extensive discussions covering the entire field of chromosomal aberrations: abnormalities found in human tumor cells, the pathogenic mechanisms they reveal, and the clinical implications of these changes. Emphasizes aspects of cancer cytogenetics which are of direct clinical significance to oncologists. Examines various specific chromosome abnormalities associated with different neoplasms and looks at cytogenetic abnormalities accrued during disease progression. Begins with a brief introduction to the field which includes an informative summary of cytogenetic nomenclature and methology. Goes on to examine the characteristic cytogenetic abnormalities found in different neoplastic diseases, such as lymphoblastic and chronic myeloid leukemia. Also includes examples of the molecular consequences of cytogenetic aberrations in conjunction with descriptions of these abnormalities.