Enantioselective Synthesis of -Amino Acids
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- Wiley
More About This Title Enantioselective Synthesis of -Amino Acids
English
This book presents an overview of the importance of ß-amino acids in pharmaceutical sciences, and discusses the most important methods that have been developed for the preparation of enantiomerically pure compounds. Each method is described by the organic chemist who developed it, and so will be written with authoritative, first-hand knowledge.
This title is the first book to summarize new available methodologies for preparing ß-amino acids in optically pure form, a recent development in this field. The title also provides methods for synthesizing optically pure precursors to pharmacologically active substances, including ß-lacatams.
This title is the first book to summarize new available methodologies for preparing ß-amino acids in optically pure form, a recent development in this field. The title also provides methods for synthesizing optically pure precursors to pharmacologically active substances, including ß-lacatams.
English
From the Contents:
Importance of ß-Amino Acids/ "Chiral pool" method in the enantioselective synthesis of ß-amino acids/
Asymmetric addition of amines to Ó, ß- unsaturated esters and nitriles/
Addition of C-nucleophiles to chiral imines/
Enantioselective hydrogenation/
Stereoselective alkylation of ß-amino ester Ó-enolates/
Self-regeneration of stereogenic centers/
Enzymatic methods/
Synthesis of the taxol side chain.
Importance of ß-Amino Acids/ "Chiral pool" method in the enantioselective synthesis of ß-amino acids/
Asymmetric addition of amines to Ó, ß- unsaturated esters and nitriles/
Addition of C-nucleophiles to chiral imines/
Enantioselective hydrogenation/
Stereoselective alkylation of ß-amino ester Ó-enolates/
Self-regeneration of stereogenic centers/
Enzymatic methods/
Synthesis of the taxol side chain.
