Title Details

Stephen J. Forman, MD, Director, Department of Hematology and Bone Marrow Transplantation; Staff Physician, Division of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA.

Karl G. Blume, MD, Professor of Medicine, Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, Stanford, California, USA.

Robert S. Negrin, MD, Associate Professor of Medicine, Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Contributors, ix

Preface to the First Edition, xvii

Preface to the Second Edition, xviii

Preface to the Third Edition, xix

Preface to the Fourth Edition, xx

Thomas HCT Fourth Edition, xxi

List of Abbreviations, xxiii

SECTION 1: History and Use of Hematopoietic Cell Transplantation

1 A History of Allogeneic Hematopoietic Cell Transplantation, 3
E. Donnall Thomas

2 The History of Autologous Hematopoietic Cell Transplantation, 8
James O. Armitage

3 Uses and Growth of Hematopoietic Cell Transplantation, 15
Mary M. Horowitz

SECTION 2: Scientifi c Basis for Hematopoietic Cell Transplantation

Section 2a: Hematopoiesis and Stem Cell Biology

4 Generation of Defi nitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells, 27
Laurence Dahéron & David T. Scadden

5 Biology of Hematopoietic Stem and Progenitor Cells, 36
Susan Prohaska & Irving Weissman

6 Molecular Biology of Stem Cell Renewal, 64
Peter M. Lansdorp

7 Cellular Biology of Hematopoiesis, 72
Catherine M. Flynn & Catherine M. Verfaillie

8 Expansion of Hematopoietic Stem Cells, 88
Colleen Delaney & Irwin Bernstein

9 Mesenchymal Stromal Cells and Hematopoietic CellTransplantation, 102
Edwin M. Horwitz

10 Genetic Manipulation of Hematopoietic Stem Cells, 116
Grant D. Trobridge & Hans-Peter Kiem

Section 2b: Immunology

11 Overview of Hematopoietic Cell Transplantation Immunology, 131
Paul J. Martin

12 Histocompatibility, 145
Eric Mickelson & Effie W. Petersdorf

13 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation, 163
Michael R. Verneris & Jeffrey S. Miller

14 Murine Models of Graft-versus-Host Disease and Graft-versus-Tumor Effect, 176
Robert Korngold & Thea M. Friedman

15 Mechanisms of Tolerance, 188
Megan Sykes

16 The Pathophysiology of Graft-Versus-Host Disease, 208
James L.M. Ferrara & Joseph H. Antin

17 Immune Reconstitution Following Hematopoietic Cell Transplantation, 222
Robertson Parkman & Kenneth I. Weinberg

18 The Human Graft-versus-Tumor Response – and How to Exploit It, 232
Edus H. Warren

19 Dendritic Cells in Hematopoietic Cell Transplantation, 248
Miriam Merad, Matthew P. Collin & Edgar G. Engleman

20 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 264
Judith A. Shizuru

Section 2c: Technical Aspects

21 Pharmacologic Basis for High-dose Chemotherapy, 289
James H. Doroshow & Timothy W. Synold

22 High-dose Preparatory Regimens, 316
William I. Bensinger

23 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 333
Jeffrey Y.C. Wong & Timothy Schultheiss

24 Radioimmunotherapy and Hematopoietic Cell Transplantation, 351
Damian J. Green & Oliver W. Press

25 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation, 365
Paul J. Martin

26 The Detection and Signifi cance of Minimal Residual Disease, 376
Jerald P. Radich & Marilyn L. Slovak

27 Pathology of Hematopoietic Cell Transplantation, 390
Howard M. Shulman, Robert C. Hackman & George E. Sale

28 Biostatistical Methods in Hematopoietic Cell Transplantation, 406
Joyce C. Niland & Paul Frankel

29 Outcomes Research in Hematopoietic Cell Transplantation, 428
Stephanie J. Lee

SECTION 3: Patient-oriented Issues in Hematopoietic Cell Transplantation

30 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 445
Karl G. Blume & Robert A. Krance

31 Nursing Role in Hematopoietic Cell Transplantation, 461
Rosemary C. Ford & Mihkaila M. Wickline

32 Ethical Issues in Hematopoietic Cell Transplantation, 478
David S. Snyder

33 Psychosocial Issues in Hematopoietic Cell Transplantation, 488
Richard P. McQuellon & Michael Andrykowski

34 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients, 502
Karen L. Syrjala & Samantha Burns Artherholt

35 Sexuality Following Hematopoietic Cell Transplantation: An Important Health-related Quality of Life Issue, 515
D. Kathryn Tierney

36 Hematopoietic Cell Transplantation: The Patient's Perspective, 526
Susan K. Stewart

SECTION 4: Sources of Hematopoietic Cells for Hematopoietic Cell Transplantation

37 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation, 535
Phyllis I. Warkentin & Elizabeth J. Shpall

38 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries, 544
Dennis L. Confer, John P. Miller & Jeffrey W. Chell

39 Cord Blood Hematopoietic Cell Transplantation, 559
Hal E. Broxmeyer & Franklin O. Smith

40 In Utero Transplantation, 577
Alan W. Flake & Esmail D. Zanjani

41 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy, 590
Thomas C. Shea & John F. DiPersio

42 Removal of Tumor Cells from the Hematopoietic Graft, 605
John G. Gribben

43 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation, 618
Norbert Schmitz

44 Cryopreservation of Hematopoietic Cells, 631
Scott D. Rowley

45 Use of Recombinant Growth Factors After Hematopoietic Cell Transplantation, 645
Jürgen Finke & Roland Mertelsmann

46 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors, 657
Claudio Anasetti, Franco Aversa & Andrea Velardi

47 Hematopoietic Cell Transplantation from Unrelated Donors, 675
Effie W. Petersdorf

48 Donor Selection for Hematopoietic Cell Transplantation, 692
Ann E. Woolfrey

SECTION 5: Hematopoietic Cell Transplantation for Acquired Diseases

49 Hematopoietic Cell Transplantation for Aplastic Anemia, 707
George E. Georges & Rainer Storb

50 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, 727
Robert P. Witherspoon

51 Allogeneic and Autologous Transplantation for Chronic Myeloid Leukemia, 734
Jerald P. Radich & Ravi Bhatia

52 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia, 751
Charlotte M. Niemeyer & Franco Locatelli

53 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia, 761
Frederick R. Appelbaum

54 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia, 775
Julie-An M. Talano, James T. Casper & David A. Margolis

55 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults, 791
Stephen J. Forman

56 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children, 806
Parinda A. Mehta & Stella M. Davies

57 Hematopoietic Cell Transplantation for Myelodysplastic Syndrome and Myeloproliferative Disorders, 827
H. Joachim Deeg

58 Hematopoietic Cell Transplantation for Multiple Myeloma, 845
Muzaffar H. Qazilbash & Sergio A. Giralt

59 Hematopoietic Cell Transplantation for Hodgkin's Disease, 860
Philip J. Bierman & Auayporn Nademanee

60 Non-Hodgkin's Lymphoma, 878
Laura J. Johnston & Sandra J. Horning

61 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia, 897
David B. Miklos

62 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL-) Amyloidosis, 914
Raymond L. Comenzo & Morie A. Gertz

63 Hematopoietic Cell Transplantation for Breast Cancer, 931
Yago Nieto & Elizabeth J. Shpall

64 Hematopoietic Cell Transplantation in Germ Cell Tumors, 948
Christie J. Moore, Brandon Hayes-Lattin & Craig R. Nichols

65 Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors, 958
Richard W. Childs & Ramaprasad Srinivasan

66 Hematopoietic Cell Transplantation for Neuroblastoma, 970
Jason Law & Katherine K. Matthay

67 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors, 985
David M. Loeb & Allen R. Chen

68 Hematopoietic Cell Transplantation for Patients with Human Immunodefi ciency Virus Infection, 1001
John A. Zaia, Amrita Krishnan, & John J. Rossi

69 Hematopoietic Cell Transplantation for Autoimmune Diseases, 1014
Richard A. Nash

70 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies, 1030
Vinod Pullarkat & Stephen J. Forman

71 Reduced-intensity Conditioning Followed by Hematopoietic Cell Transplantation for Hematologic Malignancies, 1043
Brenda M. Sandmaier & Rainer Storb

72 Management of Relapse after Hematopoietic Cell Transplantation, 1059
Ginna G. Laport & Robert S. Negrin

SECTION 6: Hematopoietic Cell Transplantation for Inherited Diseases

73 Hematopoietic Cell Transplantation for Thalassemia, 1079
Guido Lucarelli & Javid Gaziev

74 Hematopoietic Cell Transplantation for Sickle Cell Disease, 1090
Mark C. Walters

75 Hematopoietic Cell Transplantation for Immunodefi ciency Diseases, 1105
Trudy N. Small, Wilhelm Friedrich, & Richard J. O'Reilly

76 Hematopoietic Cell Transplantation for Osteopetrosis, 1125
Peter F. Coccia

77 Hematopoietic Cell Transplantation for Storage Diseases, 1136
Charles Peters

78 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders, 1163
Rajni Agarwal

79 Hematopoietic Cell Transplantation for Fanconi's Anemia, 1178
John E. Wagner, Margaret L. MacMillan, & Arleen D. Auerbach

SECTION 7: Complications of Hematopoietic Cell Transplantation

80 Mechanisms and Treatment of Graft Failure, 1203
Robert Lowsky & Hans Messner

81 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation, 1219
Margaret R. O'Donnell

82 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation, 1226
Jeffrey McCullough

83 Vascular Access and Complications, 1244
I. Benjamin Paz

84 Pharmacologic Prevention of Acute Graft-Versus-Host Disease, 1257
Nelson J. Chao & Keith M. Sullivan

85 T-Cell Depletion to Prevent Graft-versus-Host Disease, 1275
Robert J. Soiffer

86 Manifestations and Treatment of Acute Graft-Versus-Host Disease, 1287
Corey Cutler & Joseph H. Antin

87 Chronic Graft-versus-Host Disease: Clinical Manifestations and Therapy, 1304
Steven Z. Pavletic & Georgia B. Vogelsang

88 Bacterial Infections, 1325
Helen L. Leather & John R. Wingard

89 Fungal Infections after Hematopoietic Cell Transplantation, 1346
Janice (Wes) M.Y. Brown

90 Cytomegalovirus Infection, 1367
John A. Zaia

91 Herpes Simplex Virus Infections, 1382
James I. Ito

92 Varicella-zoster Virus Infections, 1388
Dora Y. Ho & Ann M. Arvin

93 Epstein–Barr Virus Infection, 1410
Wen-son Hsieh & Richard F. Ambinder

94 Adenoviruses, Respiratory Viruses, HHV-6, HHV-7, HHV-8, Papovaviruses and Other Viruses After Hematopoietic Cell Transplantation, 1419
Michael Boeckh

95 Gastrointestinal and Hepatic Complications, 1434
Simone I. Strasser & George B. McDonald

96 Lung Injury Following Hematopoietic Cell Transplantation, 1456
Kenneth R. Cooke & Gregory A. Yanik

97 Kidney and Bladder Complications of Hematopoietic Cell Transplantation, 1473
Sangeeta Hingorani

98 Endocrine Complications Following Hematopoietic Cell Transplantation, 1487
Fouad R. Kandeel

99 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation, 1523
Anne Poon & Lowan Ly

100 Critical Care of the Hematopoietic Cell Transplant Recipient, 1539
Gundeep S. Dhillon & Norman W. Rizk

101 Nutrition Support of the Hematopoietic Cell Transplant Recipient, 1551
Polly Lenssen & Saundra Aker

102 Pain Management, 1570
Noelle V. Frey & Jonathan R. Gavrin

103 Oral Complications of Hematopoietic Cell Transplantation, 1589
Mark M. Schubert & Douglas E. Peterson

104 Growth and Development after Hematopoietic Cell Transplantation, 1608
Jean E. Sanders

105 Delayed Nonmalignant Complications after Hematopoietic Cell Transplantation, 1620
Mary E.D. Flowers & H. Joachim Deeg

106 Secondary Malignancies after Hematopoietic Cell Transplantation, 1638
Smita Bhatia & Ravi Bhatia

107 Neurologic Complications of Hematopoietic Cell Transplantation, 1653
Harry Openshaw

108 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients, 1664
Trudy N. Small

SECTION 8: Looking Forward

109 Hematopoietic Cell Transplantation in the Future, 1673
Ernest Beutler

Colorplates, facing page 514
Robert C. Hackman

Index, 1677