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More About This Title When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death
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When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death offers the most thorough, cutting-edge coverage of this field since publication of the acclaimed first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised to include major advances in research, this new edition features relevant discussion of:
* The impact of genomics and proteomics
* Gene therapy and pharmacogenetics
* The role of mitochondria
* Caspase-independent and non-apoptotic cell death
* Evolution of mechanisms
With the manipulation of programmed cell death in clinical situations now in the foreseeable future, When Cells Die II also addresses the role of apoptosis in specific organ systems-the immune system, nervous system, and gastrointestinal tract-as well as different disease states, including viral infection, cancer, and myocardial infarct.
Expertly edited to provide detailed cross-referencing, consistency of style, and a logical progression of topics, When Cells Die II is the definitive resource for understanding current cell death science. It will prove an invaluable text for advanced undergraduate, graduate, and medical students, postdoctoral fellows, scientists, and clinicians in cell biology, immunology, developmental biology, neuroscience, and cancer research.
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Dr. Richard Lockshin's doctoral thesis introduced the term and concept of programmed cell death, and his laboratory has been involved in several of the major advances in the field. Following his training at Harvard, he completed his postdoctoral training at the University of Edinburgh, and subsequently taught at the University of Rochester School of Medicine and Dentistry and St. John's University, where he is Professor of Biology. He has well over 100 publications on the subject, including five books. He has won several prizes for his work and has held several scientific offices, including the founding chair of the Gordon Conferences on Cell Death, and co-founder and first president of the International Cell Death Society.
Dr. Zahra Zakeri was originally trained as a geneticist and virologist and, following her post-doctoral training at Columbia University, working on germ cell development, embarked on the study of apoptosis. She has been a leader in the development of many ideas in the field, including identification of the correlation between the synthesis of growth factors and cell death, the role of cell death in congenital malformations, measurement of DNA fragmentation in situ, recognition of the role of lysosomes and macrophages in cell death and its measurement, and the relationship of cell cycle to cell death. She was a cofounder of the Gordon Conferences on Cell Death and the International Cell Death Society, of which she is currently President. She has been a featured speaker in more than 20 countries.
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CONTRIBUTORS, VII
PREFACE, XI
SECTION I CELL DEATH ORIGIN AND PROGRESSION
1 INTRODUCTION, 3
Richard A. Lockshin and Zahra Zakeri
SECTION II BIOLOGICAL ROLE OF CELL DEATH IN DEVELOPMENT AND HOMEOSTASIS
2 CELL DEATH: SHAPING AN EMBRYO, 27
Zahra Zakeri and Richard A. Lockshin
3 CELL DEATH IN DICTYOSTELIUM: ASSESSING A GENETIC APPROACH, 59
Jean-Pierre Levraud, Myriam Adam, Marie-Françoise Luciani, Laurence Aubry, Gérard Klein, and Pierre Golstein
4 PROGRAMMED CELL DEATH IN DROSOPHILA MELANOGASTER, 79
Loretta Dorstyn and Sharad Kumar
5 CELL DEATH IN PLANT DEVELOPMENT AND DEFENSE, 99
Ron Mittler and Alice Y. Cheung
6 REGULATION OF APOPTOSIS BY EXTRACELLULAR MATRIX DURING POSTEMBRYONIC DEVELOPMENT IN XENOPUS LAEVIS, 123
Atsuko Ishizuya-Oka, Tosikazu Amano, Liezhen Fu, and Yun-Bo Shi
7 APOPTOSIS IN THE IMMUNE SYSTEM, 143
Alexandra Brás, David García-Domingo, and Carlos Martinez-A.
8 CELL DEATH IN NEURONAL DEVELOPMENT AND MAINTENANCE, 175
Aviva M. Tolkovsky, Edward T. W. Bampton, and Cristoph G. Goemans
9 CELL TURNOVER: INTESTINE AND OTHER TISSUES, 201
James W. Wilson and Christopher S. Potten
10 CELL DEATH, AGING PHENOTYPES, AND MODELS OF PREMATURE AGING, 241
Huber R. Warner
SECTION III HOW CELL DEATH IS CARRIED OUT
11 SURVIVAL FACTORS, 257
David L. Vaux
12 CASPASE-INDEPENDENT AND AUTOPHAGIC PROGRAMMED CELL DEATH, 275
Wilfried Bursch, Adolf Ellinger, Christopher Gerner, and Rolf Schulte-Hermann
13 THE RECOGNITION AND ENGULFMENT OF APOPTOTIC CELLS BY PHAGOCYTES, 311
Raymond B. Birge
14 CELL CYCLE GENES: pRb AND p53, 339
Nianli Sang and Antonio Giordano
15 MITOCHONDRIA AND OXIDATION IN THE REGULATION OF CELL DEATH, 381
John D. Robertson, Sten Orrenius, and Boris Zhivotovsky
SECTION IV DEREGULATION OF CELL DEATH IN DISEASE AND FUTURE INTERVENTION
16 THE USE OF PROTEOMICS TO IDENTIFY AND CHARACTERIZE CELL DEATH PROTEINS, 405
Xavier Saelens, Geert van Loo, Kris Gevaert, Joel Vanderkerckhove, and Peter Vandenabeele
17 CELL DEATH IN VIRAL INFECTIONS, 435
Ying-bei Chen, Yihru Fannjiang, and J. Marie Hardwick
18 CELL DEATH IN CANCER AND CANCER THERAPY, 461
Simone Fulda and Klaus-Michael Debatin
19 THE ROLE OF APOPTOSIS IN MYOCARDIAL INFARCTION AND HEART FAILURE, 483
Kartik Mani, Chang-Fu Peng, Gregg Rosner, and Richard N. Kitsis
INDEX, 521
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"…thoroughly researched, highly readable, and informative." (E-STREAMS, March 2005)
