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Drug Delivery: Principles and Applications
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An indispensable tool for those working at the front lines of new drug development
Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery.
Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures.
Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery
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BINGHE WANG, PhD, is a professor and Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scientist in the Department of Chemistry, Georgia State University. He is Editor in Chief of Medicinal Research Reviews and a member of the Long-Range Planning Committee of the American Chemical Society, Division of Medicinal Chemistry.

TERUNA SIAHAAN, PhD, is a professor in the Pharmaceutical Chemistry Department, University of Kansas, and a Fellow of the American Association of Pharmaceutical Scientists.

RICHARD A. SOLTERO, PhD, President of PharmaDirections, Inc., is an executive- level scientist with extensive experience managing multisite and multinational pharmaceutical and biotechnology labs.

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Preface vii

List of Contributors ix

1 Factors That Impact the Developability of Drug Candidates: An Overview 1
Chao Han and Binghe Wang

2 Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery 15
Anna Maria Calcagno and Teruna J. Siahaan

3 Pathways for Drug Delivery to the Central Nervous System 29
Yan Zhang and Donald W. Miller

4 Physicochemical Properties, Formulation, and Drug Delivery 57
Dewey H. Barich, Mark T. Zell, and Eric J. Munson

5 Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery 73
William F. Elmquist

6 Presystemic and First-Pass Metabolism 83
W. Griffith Humphreys

7 Cell Culture Models for Drug Transport Studies 103
D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasandani, Amber M. Young, Erik Rytting, Bradley Yops, and Kenneth L. Audus

8 Prodrug Approaches to Drug Delivery 125
Longqin Hu

9 Receptor-Mediated Drug Delivery 167
Christopher P. Leamon and Philip S. Low

10 Oral Protein and Peptide Drug Delivery 189
Rick Soltero

11 Metabolic Activation and Drug Targeting 201
Xiangming Guan

12 Ultrasound-Mediated Drug Delivery 245
Ka-yun Ng and Terry O. Matsunaga

13 Polycationic Peptides and Proteins in Drug Delivery: Focus on Nonclassical Transport 279
Lisa A. Kueltzo and C. Russell Middaugh

14 Gene Therapy and Gene Delivery 305
Naoki Kobayashi, Makiya Nishikawa, and Yoshinobu Takakura

15 Parenteral Formulation for Peptides, Proteins, and Monoclonal Antibodies Drugs: A Commercial Development Overview 321
John A. Bontempo

16 Pulmonary Drug Delivery: Pharmaceutical Chemistry and Aerosol Technology 341
Anthony J. Hickey

17 Antibody-Directed Drug Delivery 363
Herve´ Le Calvez, John Mountzouris, Kosi Gramatikoff, and Fang Fang

18 Efflux Transporters in Drug Excretion 381
Shuzhong Zhang and Marilyn E. Morris

19 Liposomes as Drug Delivery Vehicles 411
Guijun Wang

20 Regulatory and Intellectual Property Issues in Drug Delivery Research 435
Shihong Nicolaou

Index 443

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“…this text provides an excellent overview…” (Chemistry & Industry, No 24, 19th December 2005)

“…a concise but highly readable text…I recommend this well presented and well written book…” (Chemistry World, Vol. 2 (10), October 2005)

"...the broad overview of drug delivery technology presented in this book makes it well suited as a reference volume…" (E-STREAMS, September 2005)

"…systematically examines various subject areas important to drug delivery." (Drug Discovery & Development, June 2005)

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