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More About This Title Proteomics in Cancer Research
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- Basic concepts, including setting up a proteomics laboratory, mass spectrometry, protein separations, protein array technologies, and informatics tools
- Application of emerging technologies to proteomic analysis of cancer cells and tissues, including discussion of critical issues such as characteristics of cancer cell proteomes and protein-protein interactions
- Application of proteomics approaches in clinical cancer research and a forecast of future research and applications
Critical issues that readers in cancer research need to understand are covered in detail, including:
- Advantages and limitations of different technologies
- New approaches to the molecular classification of tumors
- Discovery of new biomarkers and imaging targets and development of new proteomic platforms for profiling and screening
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Preface.
1. Essential Elements of a Proteomics Laboratory (Daniel C. Liebler).
2. Mass Spectrometry Tools for Proteomics (Li-Rong Yu, Ming Zhou, Thomas P. Conrads, and Timothy D. Veenstra).
3. Gel-Based Proteomics: An Essential Core Technology in Translational Cancer Research (Julio E. Celis, Irina Gromova, Jose Moreira, Tereza Cabezo, Fritz Rank, and Pavel Gromov).
4. 2D Gel-Based Proteomic Analysis of Cancer (Sam Hanash).
5. Analysis of Protein Posttranslational Modifications and Protein Adducts (Daniel C. Liebler).
6. Bioinformatics Tools for Proteomics (Daniel C. Liebler and David B. Friedman).
7. Tissue Profiling and Imaging by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (Robert L. Caldwell and Richard M. Caprioli).
8. SELDI-TOF Applications for Cancer and Toxicity Detection (Emanuel F. Petricoin and Lance A. Liotta).
9. Protein Microarrays: Applications for Discovery and Quantitation (Virginia Espina, Julia Wulfkuhle, Emanuel F. Petricoin III, and Lance A. Liotta).
10. Protein Arrays for Clinical Proteomics and Signal Transduction Profiling (Fiona Simpkins, Victoria Espina, Edwin Posadas, Emanuel F. Petricoin III, Lance Liotta, and Elise Kohn).
11. Tissue Microarrays in Basic Cancer Research (Stephen M. Hewitt).
12. Structural Proteomics: High Throughput Structure Determination of Whole Organism Genomes (Demetrios T. Braddock).
Index.
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