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Fundamentals of Molecular Virology, Second Edition
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More About This Title Fundamentals of Molecular Virology, Second Edition

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This new, fully revised second edition of Fundamentals of Molecular Virology is designed for university students learning about virology at the undergraduate or graduate level. Chapters cover most of the major virus families, emphasizing the unique features of each virus family. These chapters are designed to tell stories about the viruses covered, and include information on discovery, diseases and pathogenesis, virus structure, steps in viral replication, and interaction with cellular signaling pathways. This approach portrays the “personality” of each virus, helping students to learn the material and to build up their knowledge of virology, starting with smaller and simpler viruses and proceeding to more complex viruses.
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Nicholas D. Schiff, MD, CASBI is The Jerold B. Katz Professor of Neurology and Neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medical College, where he also serves as Professor of Neuroscience.

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Section I: Introduction to Virology

1. Introduction to Virology 2
Nicholas H. Acheson

2. Virus Structure and Assembly 18
Stephen C. Harrison

3. Virus Classification: The World of Viruses 31
Nicholas H. Acheson

4. Virus Entry 45
Ari Helenius

Section II: Viruses of Bacteria and Archaea

5. Single-Stranded RNA Bacteriophages 59
Jan van Duin

6. Microviruses 69
Bentley Fane

7. Bacteriophage T7 77
William C. Summers

8. Bacteriophage Lambda 85
Michael Feiss

9. Viruses of Archaea 97
David Prangishvili

Section III: Positive-Strand RNA Viruses of Eukaryotes

10. Cucumber Mosaic Virus 112
Ping Xu, Marilyn J. Roosinck

11. Picornaviruses 125
Bert L. Semler

12. Flaviviruses 137
Richard Kuhn

13. Togaviruses 148
Milton Schlesinger, Sondra Schlesinger, Richard Kuhn

14. Coronaviruses 159
Mark Denison, Michelle M. Becker

Section IV: Negative-Strand and Double-Stranded RNA Viruses of Eukaryotes

15. Paramyxoviruses and Rhabdoviruses 175
Nicholas H. Acheson, Daniel Kolakofsky, Christopher Richardson, Laurent Roux

16. Filovirouses 188
Heinz Feldman, Hans-Dieter Klenk, Nicholas H. Acheson

17. Bunyaviruses 200
Richard M. Elliott

18. Influenza Viruses 225
Terence S. Dermody, James D. Chappell

19. Reoviruses 225
Terence S. Dermody, James D. Chappell

Section V: Small DNA Viruses of Eukaryotes

20. Parvoviruses 238
Peter Beard

21. Polyomaviruses 247
Nicholas H. Acheson

22. Papillomaviruses 263
Greg Matlashewski, Lawrence Banks

Section VI: Larger DNA Viruses of Eukaryotes

23. Adenoviruses 274
Philip Branton

24. Herpesviruses 285
Bernard Roisman, Gabriella Campadelli-Fiume, Richard Longnecker

25. Baculoviruses 302
Eric B. Carstens

26. Poxviruses 312
Richard C. Condit

27. Viruses of Algae and Mimivirus 325
Michael J. Allen, William H. Wilson

Section VII: Viruses That Use A Reverse Transcriptase

28. Retroviruses 342
Alan Cochrane

29. Human Immunodeficiency Virus
Alan Cochrane

30. Hepadnaviruses 365
Christopher Richardson

Section VIII: Viroids and Prions

31. Viroids and Hepatitis Delta Virus 378
Jean-Pierre Perreault, Martin Pelchat

32. Prions 387
Dalius J. Briedis

Section IX: Host Defenses Against Virus Infection

33. Intrinsic Cellular Defenses Against Virus Infection 398
Karen Mossman, Pierre Geninm, John Hiscott

34. Innate and Adaptive Immune Responses to Virus Infection 415
Malcolm G. Baines, Karen Mossman

Section X: Antiviral Agents and Virus Vectors

35. Antiviral Vaccines 428
Brian Ward

36. Antiviral Chemotherapy
Donald M. Coen

37. Eukaryotic Virus Vectors 456

GLOSSARY 471

CREDITS 484

NAME INDEX 489

SUBJECT INDEX 491

Rénald Gilbert, Bernard Massie

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“I like the overall organization and “directness” in the writing. The chapter outlines that cover the basic features of the virus discussed are quite useful. The illustrations are clear and easy to interpret.”  -Michael Graves, University of Massachusetts – Lowell

“Having each chapter that covers a specific virus written by an expert in the field then having Acheson bring the material into a common style is an excellent approach. I enjoy the slight stylistic differences that I find in the chapters, but Acheson has a direct and concise approach that makes the information throughout the text understandable for students. Chapters are short and direct. The table of contents is informative. Sections within the chapters are logically organized and headings are informative. The boxes provide interesting side topics in an extremely concise manner. Overall, I find Acheson to be an excellent text.” -William Tapprich, University of Nebraska – Omaha

“The conceptual approach to virus biology is the greatest strength of the text. The book has the appropriate level of molecular detail and it is presented in a manner that an undergraduate can readily grasp. It is a highly readable text.” -Sharon Roberts, Auburn University

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