Title Details

Dr Hussain Saba, James A. Haley Veterans Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA.

Dr Harold Roberts, School of Medicine, Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA.

Contributors, vii

Preface, x

Acknowledgments, xi

1 Theories of Blood Coagulation: Basic Concepts and Recent Updates, 1
Dougald M. Monroe and Maureane Hoffman

2 Vascular Endothelium, Infl uence on Hemostasis: Past and Present, 14
Hussain I. Saba and Sabiha R. Saba

3 Coagulation Testing: Basic and Advanced Clinical Laboratory Tests, 30
Nils Egberg and Margareta Blombäck

4 Factor VIII Defi ciency or Hemophilia A: Clinical Bleeding and Management, 45
Pier Mannuccio Mannucci and Massimo Franchini

5 Factor IX Defi ciency or Hemophilia B: Clinical Manifestations and Management, 57
Raj S. Kasthuri, Harold R. Roberts, and Paul E. Monahan

6 Factor XI Deficiency or Hemophilia C, 71
Charles E. Bane, Anne T. Neff, and David Gailani

7 Factor VIII and IX Inhibitors in Hemophilia, 82
Meera Chitlur and Jeanne Lusher

8 Treatment Options for Acquired Hemophilia, 93
Anjali Sharathkumar and David Green

9 Factor XII Deficiency or Hageman Factor Deficiency, 112
Evi X. Stavrou and Alvin H. Schmaier

10 Inherited Combined Factor Deficiency States, 127
Asma Latif and Louis Aledort

11 Acute and Chronic Immune Thrombocytopenia: Biology, Diagnosis, and Management, 137
Samir Dalia and Benjamin Djulbegovic

12 Disseminated Intravascular Coagulation: Diagnosis and Management, 151
Stephanie J. Davis and Craig M. Kessler

13 Mechanisms of Fibrinolysis and Basic Principles of Management, 169
John W. Weisel and Rustem I. Litvinov

14 Post-thrombotic Syndrome, 186
Jean-Philippe Galanaud and Susan R. Kahn

15 Von Willebrand Disease: Clinical Aspects and Practical Management, 197
Francesco Rodeghiero, Alberto Tosetto, and Giancarlo Castaman

16 Platelets in Hemostasis: Inherited and Acquired Qualitative Disorders, 209
Noman Ashraf and Hussain I. Saba

17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis, 236
James H. Morrissey

18 Thrombotic Microangiopathy: Biology, Diagnosis, and Management, 246
Samir Dalia and Hussain I. Saba

19 Hemostasis and Aging, 259
Lodovico Balducci

20 Hemostatic Problems in Chronic and Acute Liver Disease, 271
Ton Lisman and Robert J. Porte

21 Cancer and Thrombosis, 284
Erica A. Peterson and Agnes Y. Y. Lee

22 An Update on Low-Molecular-Weight Heparins, 296
Jawed Fareed, Debra Hoppensteadt, and Walter P. Jeske

Index, 315

Color plate section can be found facing page 212

“This new handbook will cover all aspects of the practical mangement of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment and day-to-day management. It will distil the most clinically relevant material from the literature for all those working in the field of haemostasis and thrombosis.”  (Kingbook73's Medical Ebook and Video Collection, 20 September 2014)