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More About This Title Counseling About Cancer: Strategies for Genetic Counseling, Third Edition
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Katherine Schneider received her Master's Degree in Public Health from Yale University School of Medicine in 1986 and was certified as a genetic counselor by the American Board of Medical Genetics in 1987. She has almost 20 years' experience as a genetic counselor and has been a cancer genetic counselor for the past 13 years. She is currently the Senior Genetic Counselor at the Dana-Farber Cancer Institute in Boston, MA, which has active high risk clinics and predictive testing programs.
English
FOREWORD, XI
PREFACE, XIII
ACKNOWLEDGMENTS, XV
CHAPTER 1: CANCER EPIDEMIOLOGY, 1
1.1. CANCER STATISTICS, 1
1.2. CANCER ETIOLOGY, 10
1.3. CASE EXAMPLES, 18
1.4. FURTHER READING, 21
CHAPTER 2: CANCER DETECTION AND TREATMENT, 23
2.1. THE DIAGNOSIS OF CANCER, 23
2.2. TUMOR CLASSIFICATION, 31
2.3. CANCER TREATMENT, 37
2.4. FURTHER READING, 45
CHAPTER 3: CANCER BIOLOGY, 47
3.1. THE MALIGNANT CELL, 47
3.2. CARCINOGENESIS 52
3.3. ONCOGENES, 59
3.4. TUMOR SUPPRESSOR GENES, 64
3.5. EPIGENETIC MECHANISMS, 70
3.6. FURTHER READING, 73
CHAPTER 4: HEREDITARY CANCER SYNDROMES, 75
4.1. ATAXIA TELANGIECTASIA, 75
4.2. AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALSO CANALE–SMITH SYNDROME), 77
4.3. BECKWITH–WIEDEMANN SYNDROME (ALSO EXOMPHALOS MACROGLOSSIA GIGANTISM [EMG] SYNDROME), 78
4.4. BIRT–HOGG–DUBÉ SYNDROME, 80
4.5. BLOOM SYNDROME, 82
4.6. BLUE RUBBER BLEB NEVUS SYNDROME (ALSO TERMED BEAN SYNDROME), 83
4.7. BREAST–OVARIAN CANCER SYNDROME, HEREDITARY, 84
4.8. CARNEY COMPLEX, TYPES I AND II (INCLUDES NAME SYNDROME AND LAMB SYNDROME), 87
4.9. DIAMOND–BLACKFAN ANEMIA, 89
4.10. FAMILIAL ADENOMATOUS POLYPOSIS (ALSO ATTENUATED FAP,GARDNER’S SYNDROME, TURCOT SYNDROME, AND HEREDITARY DESMOID DISEASE), 90
4.11. FANCONI ANEMIA, 93
4.12. GASTRIC CANCER, HEREDITARY DIFFUSE, 95
4.13. GASTROINTESTINAL STROMAL TUMOR, FAMILIAL (ALSO MULTIPLE GI AUTONOMIC NERVE TUMORS), 97
4.14. JUVENILE POLYPOSIS (INCLUDES HEREDITARY MIXED POLYPOSIS), 98
4.15. LEIOMYOMATOSIS RENAL CELL CANCER, HEREDITARY, 100
4.16. LI–FRAUMENI SYNDROME, 101
4.17. LYNCH SYNDROME (ALSO TERMED HNPCC), 105
4.18. MELANOMA, CUTANEOUS MALIGNANT (INCLUDES FAMILIAL ATYPICAL MOLE-MALIGNANT MELANOMA SYNDROME, DYSPLASTIC NEVUS SYNDROME, AND MELANOMA–ASTROCYTOMA SYNDROME), 109
4.19. MULTIPLE ENDOCRINE NEOPLASIA, TYPE 1 (ALSO WERMER SYNDROME), 111
4.20. MULTIPLE ENDOCRINE NEOPLASIA, TYPE 2 (ALSO SIPPLE SYNDROME, FAMILIAL MEDULLARY THYROID CARCINOMA SYNDROME), 113
4.21. MYH-ASSOCIATED POLYPOSIS, 115
4.22. NEUROBLASTOMA, FAMILIAL, 116
4.23. NEUROFIBROMATOSIS, TYPE 1 (ALSO VON RECKLING HAUSEN DISEASE), 118
4.24. NEUROFIBROMATOSIS, TYPE 2, 119
4.25. NEVOID BASAL CELL CARCINOMA SYNDROME (ALSO GORLIN SYNDROME, BASAL CELL NEVUS SYNDROME), 121
4.26. PARAGANGLIOMA–PHEOCHROMOCYTOMA SYNDROME, HEREDITARY (INCLUDING CARNEY–STRATAKIS SYNDROME), 123
4.27. PEUTZ-JEGHERS SYNDROME, 125
4.28. PTEN HAMARTOMA SYNDROME (PHS) (ALSO COWDEN SYNDROME; INCLUDES BANNAYAN–RILEY–RUVALCABA SYNDROME AND PROTEUS SYNDROME), 127
4.29. RENAL CELL CARCINOMA, HEREDITARY PAPILLARY, 130
4.30. RETINOBLASTOMA, HEREDITARY, 131
4.31. ROTHMUND–THOMSON SYNDROME, 133
4.32. TUBEROUS SCLEROSIS COMPLEX (TSC), 134
4.33. VON HIPPEL LINDAU SYNDROME, 137
4.34. WERNER SYNDROME (ALSO TERMED PROGERIA OF THE ADULT), 139
4.35. WILMS TUMOR, FAMILIAL (INCLUDES DENYS-DRASH SYNDROME, FRASIER SYNDROME, WAGR SYNDROME), 141
4.36. XERODERMA PIGMENTOSUM (INCLUDES XP/CS COMPLEX, XP VARIANT), 143
4.37. FURTHER READING, 145
CHAPTER 5: ALL ABOUT BREAST CANCER, 151
5.1. OVERVIEW OF BREAST CANCER, 151
5.2. BREAST CANCER MANAGEMENT: SCREENING, DIAGNOSIS, AND TREATMENT, 162
5.3. BREAST CANCER SYNDROMES, 171
5.4. FURTHER READING, 184
CHAPTER 6: ALL ABOUT COLORECTAL CANCER, 187
6.1. OVERVIEW OF COLORECTAL CANCER, 187
6.2. CRC MANAGEMENT: SCREENING, DIAGNOSIS, AND TREATMENT, 199
6.3. CRC SYNDROMES, 207
6.4. FURTHER READING, 218
CHAPTER 7: COLLECTING AND INTERPRETING CANCER HISTORIES, 221
7.1. COLLECTING A CANCER HISTORY, 221
7.2. CHALLENGES TO COLLECTING AN ACCURATE HISTORY, 242
7.3. INTERPRETING A CANCER HISTORY, 246
7.4. CASE EXAMPLES, 255
7.5. FURTHER READING, 266
CHAPTER 8: CANCER RISK COMMUNICATION, 267
8.1. GENETIC COUNSELING AND RISK PERCEPTION, 267
8.2. THE COMMUNICATION OF RISK, 278
8.3. COUNSELING CLIENTS AT VARIOUS RISKS, 289
8.4. CASE EXAMPLES, 298
8.5. FURTHER READING, 306
CHAPTER 9: GENETIC TESTING AND COUNSELING, 309
9.1. THE LOGISTICS OF ARRANGING TESTS, 309
9.2. PRETEST COUNSELING, 325
9.3. RESULTS DISCLOSURE AND FOLLOW-UP, 337
9.4. CASE EXAMPLES, 346
9.5. FURTHER READING, 356
CHAPTER 10: PSYCHOSOCIAL ASPECTS OF CANCER COUNSELING, 357
10.1. THE PSYCHOSOCIAL FEATURES OF CLIENTS, 357
10.2. MAKING A PSYCHOSOCIAL ASSESSMENT, 379
10.3. PROVIDING ADDITIONAL EMOTIONAL SUPPORT, 394
10.4. CASE EXAMPLES, 400
10.5. FURTHER READING, 407
CHAPTER 11: ETHICAL ISSUES IN CANCER GENETIC COUNSELING, 409
11.1. BIOETHICAL PRINCIPLES AND GUIDELINES, 409
11.2. STRATEGIES FOR RESOLVING ETHICAL DILEMMAS, 423
11.3. TYPES OF ETHICAL DILEMMAS IN CANCER GENETIC COUNSELING, 431
11.4. ISSUES OF JUSTICE, 442
11.5. FURTHER READING, 443
APPENDIX A: SPECIFIC TUMOR TYPES AND ASSOCIATED SYNDROMES, 445
APPENDIX B: REVIEW OF BASIC PEDIGREE SYMBOLS, 457
INDEX, 459
