Biomimetic Approaches for Biomaterials Development
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More About This Title Biomimetic Approaches for Biomaterials Development
English
Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration.
The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering.
The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.
The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering.
The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.
English
João F. Mano (CEng, PhD, DSc) is an Associate Professor at the Polymer Engineering Department, University of Minho, Portugal, and principal investigator at the 3B's research group - Biomaterials, Biodegradables and Biomimetics. He is the former director of the Master's Program in Biomedical Engineering at the University of Minho. His current research interests include the development of new materials and concepts for biomedical applications, especially aimed at being used in tissue engineering and in drug delivery systems. In particular, he has been developing biomaterials and surfaces that can react to external stimuli, or biomimetic and nanotechnology approaches to be used in the biomedical area. J.F. Mano authored more than 330 papers in international journals and three patents. He belongs to the editorial boards of 5 well-established international journals. J.F. Mano awarded the 'Stimulus to Excellence' by the Portuguese Minister for Science and Technology in 2005, the 'Materials Science and Technology Prize', attributed by the Federation of European Materials Societies in 2007 and the major 'BES innovation award' in 2010.
English
PREFACE
PART I: Examples of Natural and Nature-Inspired Materials
BIOMATERIALS FROM MARINE-ORIGIN BIOPOLYMERS
Taking Inspiration from the Sea
Marine-Origin Biopolymers
Marine-Based Tissue Engineering Approaches
Conclusions
HYDROGELS FROM PROTEIN ENGINEERING
Introduction
Principles of Protein Engineering
Structural Diversity and Applications of Protein-Engineered Hydrogels
Development of Biomimetic Protein-Engineered Hydrogels for Tissue Engineering Applications
Conclusions and Future Perspective
COLLAGEN-BASED BIOMATERIALS FOR REGENERATIVE MEDICINE
Introduction
Collagens In Vivo
Collagen In Vitro
Collagen Hydrogels
Collagen Sponges
Multichannel Collagen Scaffolds
What Tissues Do Collagen Biomaterials Mimic? (see Table 3.1)
Concluding Remarks
SILK-BASED BIOMATERIALS
Introduction
Silk Proteins
Mechanical Properties
Biomedical Applications of Silk
Final Remarks
ELASTINLIKE MACROMOLECULES
General Introduction
Materials Engineering - an Overview on Synthetic and Natural Biomaterials
Elastin as a Source of Inspiration for Nature-Inspired Polymers
Nature-Inspired Biosynthetic Elastins
ELRs as Advanced Materials for Biomedical Applications
Conclusions
BIOMIMETIC MOLECULAR RECOGNITION ELEMENTS FOR CHEMICAL SENSING
Introduction
Theory of Molecular Recognition
Molecularly Imprinted Polymers
Supramolecular Chemistry
5 Biomolecular Materials
Summary and Future of Biomimetic-Sensor-Coating Materials
PART II: Surfaces Aspects
BIOLOGY LESSONS FOR ENGINEERING SURFACES FOR CONTROLLING CELL- MATERIAL ADHESION
Introduction
The Extracellular Matrix
Protein Structure
Basics of Protein Adsorption
Kinetics of Protein Adsorption
Cell Communication
Cell Adhesion Background
Integrins and Adhesive Force Generation Overview
Adhesive Interactions in Cell, and Host Responses to Biomaterials
Model Systems for Controlling Integrin-Mediated Cell Adhesion
Self-Assembling Monolayers (SAMs)
Real-World Materials for Medical Applications
Bio-Inspired, Adhesive Materials: New Routes to Promote Tissue Repair and Regeneration
Dynamic Biomaterials
FIBRONECTIN FIBRILLOGENESIS AT THE CELL- MATERIAL INTERFACE
Introduction
Cell-Driven Fibronectin Fibrillogenesis
Cell-Free Assembly of Fibronectin Fibrils
Material-Driven Fibronectin Fibrillogenesis
NANOSCALE CONTROL OF CELL BEHAVIOR IN BIOINTERFACES
Nanoscale Cues in Cell Environment
Biomimetics of Cell Environment Using Interfaces
Cell Responses to Nanostructured Materials
The Road Ahead
SURFACES WITH EXTREME WETTABILITY RANGES FOR BIOMEDICAL APPLICATIONS
Superhydrophobic Surfaces in Nature
Theory of Surface Wettability
Fabrication of Extreme Water-Repellent Surfaces Inspired by Nature
Applications of Surfaces with Extreme Wettability Ranges in the Biomedical Field
Conclusions
BIO-INSPIRED REVERSIBLE ADHESIVES FOR DRY AND WET CONDITIONS
Introduction
Gecko-Like Dry Adhesives
Bioinspired Adhesives for Wet Conditions
The Future of Bio-Inspired Reversible Adhesives
LESSONS FROM SEA ORGANISMS TO PRODUCE NEW BIOMEDICAL ADHESIVES
Introduction
Composition of Natural Adhesives
Recombinant Adhesive Proteins
Production of Bio-Inspired Synthetic Adhesive Polymers
Perspectives
PART III: Hard and Mineralized Systems
INTERFACIAL FORCES AND INTERFACES IN HARD BIOMATERIAL MECHANICS
Introduction
Hard Biological Materials
Bioengineering and Biomimetics
Summary
NACRE-INSPIRED BIOMATERIALS
Introduction
Structure of Nacre
Why Is Nacre So Strong?
Strategies to Produce Nacre-Inspired Biomaterials
Conclusions
SURFACES INDUCING BIOMINERALIZATION
Mineralized Structures in Nature: the Example of Bone
Learning from Nature to the Research Laboratory
Smart Mineralizing Surfaces
In Situ Self-Assembly on Implant Surfaces to Direct Mineralization
Conclusions
BIOACTIVE NANOCOMPOSITES CONTAINING SILICATE PHASES FOR BONE REPLACEMENT AND REGENERATION
Introduction
Nanostructure and Nanofeatures of the Bone
Nanocomposites-Containing Silicate Nanophases
Final Considerations
PART IV: Systems for the Delivery of Bioactive Agents
BIOMIMETIC NANOSTRUCTURED APATITIC MATRICES FOR DRUG DELIVERY
Introduction
Biomimetic Apatite Nanocrystals
Biomedical Applications of Biomimetic Nanostructured Apatites
Biomimetic Nanostructured Apatite as Drug Delivery System
Adsorption and Release of Proteins
Conclusions and Perspectives
NANOSTRUCTURES AND NANOSTRUCTURED NETWORKS FOR SMART DRUG DELIVERY
Introduction
Stimuli and Sensitive Materials
Stimuli-Responsive Nanostructures and Nanostructured Networks
Concluding Remarks
PROGRESS IN DENDRIMER-BASED NANOCARRIERS
Fundamentals
Applications of Dendrimer-Based Polymers
Final Remarks
PART V: Lessons from Nature in Regenerative Medicine
TISSUE ANALOGS BY THE ASSEMBLY OF ENGINEERED HYDROGEL BLOCKS
Introduction
Tissue/Organ Heterogeneity In Vivo
Assembly of Engineered Hydrogel Blocks
Conclusions
INJECTABLE IN-SITU-FORMING SCAFFOLDS FOR TISSUE ENGINEERING
Introduction
Injectable In-Situ-Forming Scaffolds Formed by Electrostatic Interactions
Injectable In-Situ-Forming Scaffolds Formed by Hydrophobic Interactions
Immune Response of Injectable In-Situ-Forming Scaffolds
Injectable In-Situ-Forming Scaffolds for Preclinical Regenerative Medicine
Conclusions and Outlook
BIOMIMETIC HYDROGELS FOR REGENERATIVE MEDICINE
Introduction
Natural and Synthetic Hydrogels
Hydrogel Properties
Engineering Strategies for Hydrogel Development
Applications in Biomedicine
BIO-INSPIRED 3D ENVIRONMENTS FOR CARTILAGE ENGINEERING
Articular Cartilage Histology
Spontaneous and Forced Regeneration in Articular Cartilage
What Can Tissue Engineering Do for Articular Cartilage Regeneration?
Cell Sources for Cartilage Engineering
The Role and Requirements of the Scaffolding Material
Growth Factor Delivery In Vivo
Conclusions
SOFT CONSTRUCTS FOR SKIN TISSUE ENGINEERING
Introduction
Structure of Skin
Current Biomaterials in Wound Healing
Wound Dressings and Their Properties
Biomimetic Approaches in Skin Tissue Engineering
Final Remarks
PART I: Examples of Natural and Nature-Inspired Materials
BIOMATERIALS FROM MARINE-ORIGIN BIOPOLYMERS
Taking Inspiration from the Sea
Marine-Origin Biopolymers
Marine-Based Tissue Engineering Approaches
Conclusions
HYDROGELS FROM PROTEIN ENGINEERING
Introduction
Principles of Protein Engineering
Structural Diversity and Applications of Protein-Engineered Hydrogels
Development of Biomimetic Protein-Engineered Hydrogels for Tissue Engineering Applications
Conclusions and Future Perspective
COLLAGEN-BASED BIOMATERIALS FOR REGENERATIVE MEDICINE
Introduction
Collagens In Vivo
Collagen In Vitro
Collagen Hydrogels
Collagen Sponges
Multichannel Collagen Scaffolds
What Tissues Do Collagen Biomaterials Mimic? (see Table 3.1)
Concluding Remarks
SILK-BASED BIOMATERIALS
Introduction
Silk Proteins
Mechanical Properties
Biomedical Applications of Silk
Final Remarks
ELASTINLIKE MACROMOLECULES
General Introduction
Materials Engineering - an Overview on Synthetic and Natural Biomaterials
Elastin as a Source of Inspiration for Nature-Inspired Polymers
Nature-Inspired Biosynthetic Elastins
ELRs as Advanced Materials for Biomedical Applications
Conclusions
BIOMIMETIC MOLECULAR RECOGNITION ELEMENTS FOR CHEMICAL SENSING
Introduction
Theory of Molecular Recognition
Molecularly Imprinted Polymers
Supramolecular Chemistry
5 Biomolecular Materials
Summary and Future of Biomimetic-Sensor-Coating Materials
PART II: Surfaces Aspects
BIOLOGY LESSONS FOR ENGINEERING SURFACES FOR CONTROLLING CELL- MATERIAL ADHESION
Introduction
The Extracellular Matrix
Protein Structure
Basics of Protein Adsorption
Kinetics of Protein Adsorption
Cell Communication
Cell Adhesion Background
Integrins and Adhesive Force Generation Overview
Adhesive Interactions in Cell, and Host Responses to Biomaterials
Model Systems for Controlling Integrin-Mediated Cell Adhesion
Self-Assembling Monolayers (SAMs)
Real-World Materials for Medical Applications
Bio-Inspired, Adhesive Materials: New Routes to Promote Tissue Repair and Regeneration
Dynamic Biomaterials
FIBRONECTIN FIBRILLOGENESIS AT THE CELL- MATERIAL INTERFACE
Introduction
Cell-Driven Fibronectin Fibrillogenesis
Cell-Free Assembly of Fibronectin Fibrils
Material-Driven Fibronectin Fibrillogenesis
NANOSCALE CONTROL OF CELL BEHAVIOR IN BIOINTERFACES
Nanoscale Cues in Cell Environment
Biomimetics of Cell Environment Using Interfaces
Cell Responses to Nanostructured Materials
The Road Ahead
SURFACES WITH EXTREME WETTABILITY RANGES FOR BIOMEDICAL APPLICATIONS
Superhydrophobic Surfaces in Nature
Theory of Surface Wettability
Fabrication of Extreme Water-Repellent Surfaces Inspired by Nature
Applications of Surfaces with Extreme Wettability Ranges in the Biomedical Field
Conclusions
BIO-INSPIRED REVERSIBLE ADHESIVES FOR DRY AND WET CONDITIONS
Introduction
Gecko-Like Dry Adhesives
Bioinspired Adhesives for Wet Conditions
The Future of Bio-Inspired Reversible Adhesives
LESSONS FROM SEA ORGANISMS TO PRODUCE NEW BIOMEDICAL ADHESIVES
Introduction
Composition of Natural Adhesives
Recombinant Adhesive Proteins
Production of Bio-Inspired Synthetic Adhesive Polymers
Perspectives
PART III: Hard and Mineralized Systems
INTERFACIAL FORCES AND INTERFACES IN HARD BIOMATERIAL MECHANICS
Introduction
Hard Biological Materials
Bioengineering and Biomimetics
Summary
NACRE-INSPIRED BIOMATERIALS
Introduction
Structure of Nacre
Why Is Nacre So Strong?
Strategies to Produce Nacre-Inspired Biomaterials
Conclusions
SURFACES INDUCING BIOMINERALIZATION
Mineralized Structures in Nature: the Example of Bone
Learning from Nature to the Research Laboratory
Smart Mineralizing Surfaces
In Situ Self-Assembly on Implant Surfaces to Direct Mineralization
Conclusions
BIOACTIVE NANOCOMPOSITES CONTAINING SILICATE PHASES FOR BONE REPLACEMENT AND REGENERATION
Introduction
Nanostructure and Nanofeatures of the Bone
Nanocomposites-Containing Silicate Nanophases
Final Considerations
PART IV: Systems for the Delivery of Bioactive Agents
BIOMIMETIC NANOSTRUCTURED APATITIC MATRICES FOR DRUG DELIVERY
Introduction
Biomimetic Apatite Nanocrystals
Biomedical Applications of Biomimetic Nanostructured Apatites
Biomimetic Nanostructured Apatite as Drug Delivery System
Adsorption and Release of Proteins
Conclusions and Perspectives
NANOSTRUCTURES AND NANOSTRUCTURED NETWORKS FOR SMART DRUG DELIVERY
Introduction
Stimuli and Sensitive Materials
Stimuli-Responsive Nanostructures and Nanostructured Networks
Concluding Remarks
PROGRESS IN DENDRIMER-BASED NANOCARRIERS
Fundamentals
Applications of Dendrimer-Based Polymers
Final Remarks
PART V: Lessons from Nature in Regenerative Medicine
TISSUE ANALOGS BY THE ASSEMBLY OF ENGINEERED HYDROGEL BLOCKS
Introduction
Tissue/Organ Heterogeneity In Vivo
Assembly of Engineered Hydrogel Blocks
Conclusions
INJECTABLE IN-SITU-FORMING SCAFFOLDS FOR TISSUE ENGINEERING
Introduction
Injectable In-Situ-Forming Scaffolds Formed by Electrostatic Interactions
Injectable In-Situ-Forming Scaffolds Formed by Hydrophobic Interactions
Immune Response of Injectable In-Situ-Forming Scaffolds
Injectable In-Situ-Forming Scaffolds for Preclinical Regenerative Medicine
Conclusions and Outlook
BIOMIMETIC HYDROGELS FOR REGENERATIVE MEDICINE
Introduction
Natural and Synthetic Hydrogels
Hydrogel Properties
Engineering Strategies for Hydrogel Development
Applications in Biomedicine
BIO-INSPIRED 3D ENVIRONMENTS FOR CARTILAGE ENGINEERING
Articular Cartilage Histology
Spontaneous and Forced Regeneration in Articular Cartilage
What Can Tissue Engineering Do for Articular Cartilage Regeneration?
Cell Sources for Cartilage Engineering
The Role and Requirements of the Scaffolding Material
Growth Factor Delivery In Vivo
Conclusions
SOFT CONSTRUCTS FOR SKIN TISSUE ENGINEERING
Introduction
Structure of Skin
Current Biomaterials in Wound Healing
Wound Dressings and Their Properties
Biomimetic Approaches in Skin Tissue Engineering
Final Remarks
