Systems Biology and Synthetic Biology
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More About This Title Systems Biology and Synthetic Biology


The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.


Pengcheng Fu, Phd, is a professor in the Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing. His research interests include: biofuels and bioenergy, metabolic engineering, functional genomics, genome-scale modeling, bioprocess control, metabolomics/metabolite profiling, systems biology, and synthetic biology.

Dr. Sven Panke is an associate professor and leader of the Bioprocess Laboratory at the Department of Mechanical and Process Engineering of the ETH Zurich, Switzerland. His main interests are the design of novel biocatalysts for applications in chemistry and pharmacy by synthetic biology approaches.


Chapter 1: Introduction (Pengcheng Fu).

Chapter 2: Basics of Molecular Biology, Genetic Engineering and Metabolic Engineering (Michael X. Wang and Huidong Shi).

Chapter 3: High-Throughput Technologies and Functional Genomics (Henry Wang and Dorothea K. Thompson).

Chapter 4: Predicting the Lymph Node Status of Breast Cancer Tumors Using Gene Expression Patterns and Genomic Signal Processing (Gordon Okimoto).

Chapter 5: From Recombinant Genes to Recombinant Genomes for Systems Biology (Mitsuhiro Itaya).

Chapter 6: In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications (Andrew Joyce and Bernhard Palsson).

Chapter 7: Mathematical Modeling of Genetic Regulatory Networks: Stress Responses in Escherichia coli (Delphine Ropers, Hidde de Jong, and Johannes Geiselmann).

Chapter 8: Systems Approaches in Molecular Diagnostics and Drug Development (Martin Latterich).

Chapter 9: Yeast as a Prototype for Systems Biology (Gautham Vemuri and Jens Nielsen).

Chapter 10: Construction and Applications of Genome-Scale In Silico Metabolic Models for Strain Improvement (Sang Yup Lee, Jin Sik Kim, Hongseok Yun, Tae Yong Kim, Seung Bum Sohn, Hyun Uk Kim).

Chapter 11: Synthetic Biology: Putting Engineering into Bioengineering (Matthias Heinemann and Sven Panke).

Chapter 12: Rationals of Gene Design and de novo Gene Construction (Marcus Graf, Thomas Schoedl and Ralf Wagner).

Chapter 13: Self-replication in Chemistry and Biology (Phil Holliger and David Loakes).

Chapter 14: The Synthetic Approach for Regulatory and Metabolic Circuits (Wilson W. Wong and James C. Liao).

Chapter 15: Synthetic Genetic Networks (David Greber and Martin Fussenegger).

Chapter 16: The theory of biological robustness and its implication to cancer (Hiroaki Kitano).

Chapter 17: Nucleic Acid Engineering (Wenlong Cheng, Liang Ding, Hisakage Funabashi, Nokyoung Park, Soong Ho Um, Jianfeng Xu, and Dan Luo).

Chapter 18: Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology (Guangyi Wang and Juanita Mathews).

Chapter 19: On fundamental implications of systems and synthetic biology (Cliff Hooker).

Chapter 20: Outstanding Issues in systems and synthetic biology (Pengcheng Fu and Cliff Hooker).