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Chronopharmaceutics: Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases
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More About This Title Chronopharmaceutics: Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

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English

Chronopharmaceutics

Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

Edited by

Bi-Botti C. Youan

The first standard reference on chronopharmaceutics

As we better understand how biological processes unfold in real time through advances in chronobiology and related fields, we can create safer, more effective drugs, drug delivery systems, and disease monitoring and prevention systems. When administered in correct coordination with a patient's body rhythms, such drugs can maximize therapeutic outcome while minimizing unwanted side effects. Chronopharmaceutics presents the first standard reference text on this emerging cross-disciplinary field and its potential for therapeutic and preventive medicine.

Bringing together the latest findings from experienced investigators, this edited work presents a much-needed single source on chronopharmaceutics. After an introduction that includes a timeline of key discoveries, an overview of regula-tory, formulation, manufacturing and key resource issues associated with chronopharmaceutics, the detailed coverage examines:

  • Chronogenetics

  • Chronopharmacokinetics

  • Chronotherapy

  • Controlled release systems triggered by physical and/or chemical activation

  • Chronopharmacodynamics, chronomics, and anesthesia

  • Markers-guided chronotheranostics

Filling a gap in both the graduate classroom and the working industrial or research laboratory, Chronopharmaceutics offers students, instructors, and professionals a unique and comprehensive reference for this cutting-edge field.

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English

Bi-Botti C. Youan, PharmD, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri–Kansas City School of Pharmacy. He is on the editorial board of the Journal of Environmental Pollution; and a member of the Controlled Release Society, the American Chemical Society, and the American Association of Pharmaceutical Scientists (AAPS). Dr. Youan initiated the first AAPS Sunrise School on Chronopharmaceutical Drug Delivery in 2004. He earned his doctorate from the Université Catholique de Louvain, Brussels, Belgium.

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English

PREFACE.

ACKNOWLEDGMENTS.

CONTRIBUTORS.

ABBREVATION LIST.

INTRODUCTION: TIME, DIAGNOSTICS, AND THERAPEUTICS—BEYOND CIRCADIAN MARKER RHYTHM-GUIDED TREATMENT (Franz Halberg, Germaine Corne lissen, and Othild Schwartzkopff).

1 OVERVIEW OF CHRONOPHARMACEUTICS (Bi-Botti C. Youan).

2 CHRONOGENETICS (Franck Delaunay).

3 CHRONOPHARMACOKINETICS (Bernard Bruguerolle).

4 CHEMICAL OSCILLATOR SYSTEMS FOR CHRONOTHERAPY (Steven A. Giannos).

5 DIFFUCAPS TECHNOLOGY FOR CONTROLLED RELEASE DRUG DELIVERY (Gopi Venkatesh).

6 CHRONOTOPICt TECHNOLOGY (M. E. Sangalli, A. Maroni, L. Zema, M. Cerea, and A. Gazzaniga).

7 CHRONOTHERAPY USING EGALET TECHNOLOGY (Daniel Bar-Shalom, Clive G. Wilson, and Neena Washington).

8 CHRONSETt: AN OROS DELIVERY SYSTEM FOR CHRONOTHERAPY (Liang C. Dong, Crystal Pollock-Dove, and Patrick S.L. Wong).

9 CONTROLLED RELEASE MICROCHIPS (Karen Daniel, Hong Linh Ho Duc, Michael Cima, and Robert Langer).

10 IMPLICATIONS AND APPLICATIONS OF CIRCADIAN SUSCEPTIBILITY RHYTHMS: CHRONOMICS AND ANESTHESIA (Franz Halberg, Germaine Corne´ lissen, and Othild Schwartzkopff).

11 TREATMENT WITH OPEN EYES: MARKERS-GUIDED CHRONOTHERANOSTICS (Germaine Corne lissen, and Franz Halberg).

INDEX.

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"[This book] has the challenging subtitle "Science and technology for biological rhythm-guided therapy and prevention of diseases", which recognizes the fact, ignored by those developing pharmaceuticals, that one can also seek specific times when certain chemical structures best achieve their desired effects with least undesired consequences.... The book is recommended to all who deal with pharmaceutics, as well as with pharmacology. As noted by Bi-Botti C. Youan, whose milestones date back to the 7th century BCE, it should be part and parcel of the education of all health care providers and recipients. It could stem enormous current waste by those who have not yet acquainted themselves with phase-zero trials. Therein, timing takes first rather than last priority, as is currently the case in industry. By systematically testing new drugs at different rhythm stages at the outset, one may not only avoid discarding a useful drug if tested at the wrong time, but one may also obtain an estimate of what optimal rhythm stages may be, and assess the extent of difference in response from administering the drug at the presumably best or worst times."
—Franz Halberg, M.D., Dr. h.c. (mult.), Halberg Chronobiology Center University of Minnesota
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