Guide to NMR Spectral Interpretation
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More About This Title Guide to NMR Spectral Interpretation

English

The book is designed to provide undergraduate and graduate students with practical strategies, methods and explanations to unravel the intriguing combinations of chemical shift, integration, and multiplicity of NMR signals. In particular, it is organized in a way that basic 1H- and 13C-NMR concepts are introduced and immediately applied in a number of problems, solved and discussed in a step-by-step fashion. It contains almost exclusively real NMR data and it describes how to interpret the chemical shift, intensity and splitting pattern of the proton and carbon NMR signals (Chapters 1-5), paying attention to the effects of the magnetically non-equivalent nuclei (Chapter 4). The role of the solvent is also explained (Chapter 6), and a description of the interpretation of the most common two-dimensional NMR experiments is reported in Chapter 7. Chapter 8 is dedicated to the strategy for structural elucidation, while Chapter 9 contains exclusively summary problems with increasing levels of difficulty.
The entire learning path is aimed to provide practical tools to determine the chemical structures of small organic molecules from their 1D and 2D NMR spectra.

Extensions online:
- Solutions to summary problems are available online to prevent students from instantly getting to the answers before they have worked hard to solve the problems.
- In order to give the feeling of an “electronic” exploration of the NMR spectra, the book is also provided with additional unprocessed NMR data sets, which students can download and study by themselves.

Resources for teachers:
- Teachers will have access to all the figures of this book, in order to easily prepare their lessons. They will also be provided with a number of additional summary problems, not present in the book, to engage students in practical exercises during the course, or to be used during final examinations.

English

Antonio Randazzo is currently Full Professor of Medicinal Chemistry at University of Naples Federico II.
He obtained his master degree in Chemistry and Pharmaceutical Technology in 1995 at the University of Naples “Federico II” (Italy) with top marks and honors and his PhD in Bioactive Natural Compounds in the same University in 1999. From 1999 to 2000 he was postdoctoral fellow at The Scripps Research Institute (San Diego, CA, USA) and successively at the Vanderbilt University (Nashville, TN, USA) under the supervision of Prof. Walter Chazin. During his stay in USA, Antonio Randazzo deepened new NMR methodology for the study of biomolecules. From 2018, he is Full Professor at the Faculty of Farmacy of the University of Naples Federico II. Most of his carrier, he has been focused on the study of alternative structures of DNA, namely G-quadruplex structures. Particularly, he spent most of the last years studying DNA G-quadruplex-drug interactions using both experimental and computational approaches, with the general purpose of discovering new specific ligands for G-quadruplexes useful for therapeutic applications. Prof. Randazzo participated in the past years to several research projects with innovative and significant scientific contributions and to the development of new specific research strategies. Prof. Randazzo has co-authored about 140 publications in international journals. He is corresponding author of almost all articles dealing with drug/DNA interactions. In addition, the scientific projects carried out by Prof. Randazzo have involved interdisciplinary competences and collaborations between different research groups worldwide.
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